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ZBTB7C  -  zinc finger and BTB domain containing 7C

Homo sapiens

Synonyms: APM-1, APM1, Affected by papillomavirus DNA integration in ME180 cells protein 1, ZBTB36, ZNF857C, ...
 
 
 
 
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High impact information on ZBTB7C

  • APM-1 transcripts are detected in normal cervical keratinocytes, but not in the majority of cervical carcinoma cell lines analysed [1].
  • The APM-1 gene caused a reduction of clonal cell growth in vitro of HeLa and CaSki tumour cells [1].
  • The APM-1 gene encodes a protein with a BTB/POZ domain and four zinc fingers, and is located at chromosome 18q21 [1].
  • APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity [1].
  • These characteristics make APM-1, the first novel human gene identified in a HPV integration region, a likely candidate for the postulated tumour suppressor gene [1].

References

  1. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. Reuter, S., Bartelmann, M., Vogt, M., Geisen, C., Napierski, I., Kahn, T., Delius, H., Lichter, P., Weitz, S., Korn, B., Schwarz, E. EMBO J. (1998) [Pubmed]
 
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