Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Stmn3 - stathmin-like 3

Mus musculus

Synonyms: 9330161A03Rik, AI604839, Hippocampus abundant transcript 3, R75323, SCG10-like protein, ...

Matsuo, N. et al., Liedtke, W. et al., Horiuchi, Y. et al., Ozon, S. et al., Yoshie, M. et al.

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High impact information on Stmn3

At the molecular level, increased gene expression of SCG 10-like protein, a stathmin-related gene with microtubule destabilizing activity, was detected in the central nervous system of aging stathmin(-/-) mice [1].
The analysis of those plasmids revealed that they harbored cDNA that encodes neuronal proteins including SCLIP and CRMP-1, and those with unknown function [2].
We have isolated a novel cDNA (HiAT3: hippocampus abundant transcript 3) in the course of screening for genes that are preferentially expressed in neonatal mouse hippocampus using random 3'-directed cDNA sequencing approach [3].
In contrast, the others of stathmin family members, SCLIP and RB3 were highly expressed in stathmin-KO mice compared to WT mice [4].

Analytical, diagnostic and therapeutic context of Stmn3

Northern blot analysis as well as in situ hybridization on 14-day rat embryos showed that SCLIP mRNA is expressed only in neural structures [5].

References

Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. Liedtke, W., Leman, E.E., Fyffe, R.E., Raine, C.S., Schubart, U.K. Am. J. Pathol. (2002) [Pubmed]
Identifying novel substrates for mouse Cdk5 kinase using the yeast Saccharomyces cerevisiae. Horiuchi, Y., Asada, A., Hisanaga, S., Toh-E, A., Nishizawa, M. Genes Cells (2006) [Pubmed]
A novel SCG10-related gene uniquely expressed in the nervous system. Matsuo, N., Kawamoto, S., Matsubara, K., Okubo, K. Gene (1998) [Pubmed]
Expression of stathmin family genes in the murine uterus during early pregnancy. Yoshie, M., Tamura, K., Hara, T., Kogo, H. Mol. Reprod. Dev. (2006) [Pubmed]
SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. Ozon, S., Byk, T., Sobel, A. J. Neurochem. (1998) [Pubmed]

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