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Scn1b  -  sodium channel, voltage-gated, type I, beta

Mus musculus

Synonyms: Sodium channel subunit beta-1
 
 
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High impact information on Scn1b

  • At the subcellular level in later embryonic and postnatal mouse cardiomyocytes, Scn1b was present in T-tubules as identified by immunostaining of alpha-actinin, and in the intercalated disks as identified by immunostaining of connexin 43 [1].
  • With further development, Scn1b protein showed an enhanced expression in the trabeculated myocardium and the bundle branches [1].
  • CONCLUSION: These results demonstrate that Scn1b is expressed during mouse heart development, suggesting it can play an important role in the action potential configuration of the cardiomyocytes during heart morphogenesis [1].
  • Our results show that a voltage-gated sodium channel (Scn1b) and a voltage-gated potassium channel (Kcna1) are differentially expressed in AGS and PTZ-induced epilepsy models as well as in QYS-treated animals [2].
  • Involvement of Scn1b and Kcna1 ion channels in audiogenic seizures and PTZ-induced epilepsy [2].
 

Biological context of Scn1b

  • Chromosome mapping of the beta 1 subunit showed a single locus (Scn1b) in mouse chromosome 7 1.8 cM (+/- 1.2 cM) distal to D19F11S1h and 0.9 cM (+/- 0.9 cM) proximal to Pkca [3].
 

Analytical, diagnostic and therapeutic context of Scn1b

  • Immunohistochemistry experiments revealed comparable distribution of Scn1b protein between the different cardiac chambers at early embryonic stages [1].
  • METHODS: Scn1b mRNA levels were determined by real-time RT-PCR using embryonic hearts ranging from E9.5 to E18.5 as well as in postnatal and adult heart [1].
  • However, three silent polymorphisms in the DNA coding region indicate that Scn1b is close to qv, and is within a region of genetic identity with DBA/2J, the inbred background on which the qvJ allele arose [4].

References

  1. Temporal and spatial expression pattern of beta1 sodium channel subunit during heart development. Domínguez, J.N., Navarro, F., Franco, D., Thompson, R.P., Aránega, A.E. Cardiovasc. Res. (2005) [Pubmed]
  2. Involvement of Scn1b and Kcna1 ion channels in audiogenic seizures and PTZ-induced epilepsy. Li, X., Yang, Q., Kuang, H., Jiang, N., Hu, Y. Epilepsy Res. (2005) [Pubmed]
  3. A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. Tong, J., Potts, J.F., Rochelle, J.M., Seldin, M.F., Agnew, W.S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  4. Sequence of the voltage-gated sodium channel beta1-subunit in wild-type and in quivering mice. Grosson, C.L., Cannon, S.C., Corey, D.P., Gusella, J.F. Brain Res. Mol. Brain Res. (1996) [Pubmed]
 
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