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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CERS3  -  ceramide synthase 3

Homo sapiens

Synonyms: ARCI9, CerS3, Ceramide synthase 3, Dihydroceramide synthase 3, LAG1 longevity assurance homolog 3, ...
 
 
 
 
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High impact information on LASS3

  • These results indicate that LASS3 possesses (dihydro)ceramide synthesis activity with relatively broad substrate specificity [1].
  • In vivo, [3H]dihydrosphingosine labelling and electrospray-ionization MS revealed that overproduction of either LASS3 isoform results in increases in several ceramide species, with some preference toward those having middle- to long-chain-fatty acyl-CoAs [1].
  • We also found that, except for a weak display in skin, LASS3 mRNA expression is limited almost solely to testis, implying that LASS3 plays an important role in this gland [1].

References

  1. LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Mizutani, Y., Kihara, A., Igarashi, Y. Biochem. J. (2006) [Pubmed]
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