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Gene Review:

Sla - src-like adaptor

Mus musculus

Synonyms: SLAP-1, Slap, Slap-1, Slap1, Src-like-adapter, ...

Meijerink, P.H. et al., Sosinowski, T. et al., Dragone, L.L. et al., Alifragis, P. et al.

Meijerink, Yanakiev, Zorn, Grierson, Bikker, Dye, Kalaydjieva, Baas, Alifragis, Molnár, Parnavelas,

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High impact information on Sla

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection [1].
SRC-like adaptor protein regulates B cell development and function [2].
This gene, designated hslap, appears to be the human ortholog of the recently described gene for the murine Src-like adaptor protein (mSLAP), a candidate intermediate in the signal-transduction pathway of the Eck receptor tyrosine kinase [3].
Restricted expression of Slap-1 in the rodent cerebral cortex [4].

References

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Sosinowski, T., Killeen, N., Weiss, A. Immunity (2001) [Pubmed]
SRC-like adaptor protein regulates B cell development and function. Dragone, L.L., Myers, M.D., White, C., Sosinowski, T., Weiss, A. J. Immunol. (2006) [Pubmed]
The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene. Meijerink, P.H., Yanakiev, P., Zorn, I., Grierson, A.J., Bikker, H., Dye, D., Kalaydjieva, L., Baas, F. Eur. J. Biochem. (1998) [Pubmed]
Restricted expression of Slap-1 in the rodent cerebral cortex. Alifragis, P., Molnár, Z., Parnavelas, J.G. Gene Expr. Patterns (2003) [Pubmed]

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