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Gene Review

Kdm5c  -  lysine (K)-specific demethylase 5C

Mus musculus

Synonyms: D930009K15Rik, Histone demethylase JARID1C, Jarid1c, Jumonji/ARID domain-containing protein 1C, Kiaa0234, ...
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High impact information on Jarid1c

  • Escape from X inactivation of Smcx is preceded by silencing during mouse development [1].
  • In vitro and in vivo studies show that Xe169 is expressed from both the active and the inactive X chromosomes [2].
  • We have recently identified Smcy, a ubiquitously expressed gene, in this region and its X-chromosome homologue, Smcx [3].
  • To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes [4].
  • We found that long terminal repeats (LTRs) were decreased in the human domain of escape, but not in the majority of the conserved mouse region adjacent to Smcx in which genes were subject to X inactivation, suggesting that these repeats might be excluded from escape domains to prevent spreading of silencing [5].

Biological context of Jarid1c

  • The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties [6].

Analytical, diagnostic and therapeutic context of Jarid1c


  1. Escape from X inactivation of Smcx is preceded by silencing during mouse development. Lingenfelter, P.A., Adler, D.A., Poslinski, D., Thomas, S., Elliott, R.W., Chapman, V.M., Disteche, C.M. Nat. Genet. (1998) [Pubmed]
  2. The murine Xe169 gene escapes X-inactivation like its human homologue. Wu, J., Salido, E.C., Yen, P.H., Mohandas, T.K., Heng, H.H., Tsui, L.C., Park, J., Chapman, V.M., Shapiro, L.J. Nat. Genet. (1994) [Pubmed]
  3. Identification of a mouse male-specific transplantation antigen, H-Y. Scott, D.M., Ehrmann, I.E., Ellis, P.S., Bishop, C.E., Agulnik, A.I., Simpson, E., Mitchell, M.J. Nature (1995) [Pubmed]
  4. Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene. Carrel, L., Hunt, P.A., Willard, H.F. Hum. Mol. Genet. (1996) [Pubmed]
  5. Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse. Tsuchiya, K.D., Greally, J.M., Yi, Y., Noel, K.P., Truong, J.P., Disteche, C.M. Genome Res. (2004) [Pubmed]
  6. Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus. Sandstedt, S.A., Tucker, P.K. Mamm. Genome (2006) [Pubmed]
  7. The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Sultana, R., Adler, D.A., Edelhoff, S., Carrel, L., Lee, K.H., Chapman, V.C., Willard, H.F., Disteche, C.M. Hum. Mol. Genet. (1995) [Pubmed]
  8. Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human. Tsuchiya, K.D., Willard, H.F. Mamm. Genome (2000) [Pubmed]
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