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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pkn2  -  protein kinase N2

Rattus norvegicus

Synonyms: Cardiolipin-activated protein kinase Pak2, PAK-2, PKN gamma, Pak-2, Pak2, ...
 
 
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High impact information on Pkn2

  • Caspase-3 cleaves several essential downstream substrates involved in the expression of the apoptotic phenotype in vitro, including gelsolin, PAK2, fodrin, nuclear lamins and the inhibitory subunit of DNA fragmentation factor [1].
  • The general S6 peptide substrate determinants for liver PAK-1 resembled those for brain protein kinase C and another major liver PAK, termed PAK-2 [2].

References

  1. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Springer, J.E., Azbill, R.D., Knapp, P.E. Nat. Med. (1999) [Pubmed]
  2. Determinants of multi-site phosphorylation of peptide analogues of ribosomal protein S6 by novel protease-activated protein kinases. Wettenhall, R.E., Gabrielli, B., Morrice, N., Bozinova, L., Kemp, B.E., Stapleton, D. Pept. Res. (1991) [Pubmed]
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