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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sult1e1  -  sulfotransferase family 1E, member 1

Mus musculus

Synonyms: EST, Estrogen sulfotransferase, testis isoform, ST1E1, Ste, Sulfotransferase 1E1, ...
 
 
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Disease relevance of Sult1e1

  • Here we show that ablation of the mouse Sult1e1 gene caused placental thrombosis and spontaneous fetal loss [1].
 

High impact information on Sult1e1

  • Treatment of pregnant Sult1e1-null mice with either an anticoagulant or antiestrogen prevented the fetal loss phenotype [1].
  • Hepatic Ste mRNA transcripts were increased from undetectable levels in normal males and females to high levels in db/db mice of both sexes [2].
  • A Y chromosomal repetitive sequence identified two types of Y chromosomes in mice (Mus musculus domesticus) caught near Ste [3].

References

  1. Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Tong, M.H., Jiang, H., Liu, P., Lawson, J.A., Brass, L.F., Song, W.C. Nat. Med. (2005) [Pubmed]
  2. Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. Leiter, E.H., Chapman, H.D. J. Clin. Invest. (1994) [Pubmed]
  3. Two types of mouse (Mus musculus domesticus) Y chromosomes in Quebec. Nishioka, Y. Genome (1992) [Pubmed]
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