Gene Review:
Myo5c - myosin VC
Mus musculus
Synonyms:
9130003O20Rik, BB085560, C330029I24
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High impact information on Myo5c
- Immunolocalization in colon and exocrine pancreas indicates that Myo5c is expressed chiefly in epithelial cells [1].
- As a class V myosin of epithelial cells, Myo5c is likely to power actin-based membrane trafficking in many physiologically crucial tissues of the human body [1].
- A dominant negative approach using a GFP-Myo5c tail construct in HeLa cells reveals that the Myo5c tail selectively colocalizes with and perturbs a membrane compartment containing the transferrin receptor and rab8 [1].
References
- Human myosin-Vc is a novel class V myosin expressed in epithelial cells. Rodriguez, O.C., Cheney, R.E. J. Cell. Sci. (2002) [Pubmed]
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