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Gtf2h3  -  general transcription factor IIH,...

Mus musculus

Synonyms: 34kDa, 5033417D07Rik, BTF2, BTF2 p34, Basic transcription factor 2 34 kDa subunit, ...
 
 
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Disease relevance of Gtf2h3

 

High impact information on Gtf2h3

  • Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo [2].
  • The largest subunit of RNA polymerase II then lacks immunological and drug-sensitivity characteristics related to its phosphorylation by the TFIIH-associated kinase and gradually translocates into the nuclei independently of DNA replication and mitosis [3].
  • Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription [4].
  • Overexpression of 34kDa nucleolar PHGPx in RBL2H3 cells significantly suppressed cell death induced by actinomycin D and doxorubicin that induced damage in the nucleolus [5].
  • Unregulated transcription of protein-encoding genes in vitro is dependent on 12-subunit core RNA polymerase II and five general transcription factors; TATA binding protein (TBP), transcription factor (TF)IIB, TFIIE, TFIIF, and TFIIH [6].
 

Biological context of Gtf2h3

  • The elucidation of the specific interactions between proteins that comprise the transcription factor complex TFIIH raises the possibility that nucleotide excision repair, RNA polymerase II transcription, and cell cycle control are connected [7].

References

  1. Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Compe, E., Malerba, M., Soler, L., Marescaux, J., Borrelli, E., Egly, J.M. Nat. Neurosci. (2007) [Pubmed]
  2. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo. Lee, D., Lis, J.T. Nature (1998) [Pubmed]
  3. Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos. Bellier, S., Chastant, S., Adenot, P., Vincent, M., Renard, J.P., Bensaude, O. EMBO J. (1997) [Pubmed]
  4. Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription. Korsisaari, N., Rossi, D.J., Paetau, A., Charnay, P., Henkemeyer, M., Mäkelä, T.P. J. Cell. Sci. (2002) [Pubmed]
  5. Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells. Nakamura, T., Imai, H., Tsunashima, N., Nakagawa, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  6. A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH and recombinant TBP, TFIIB, TFIIE and TFIIF. Kotova, I., Chabes, A.L., Segerman, B., Flodell, S., Thelander, L., Björklund, S. Eur. J. Biochem. (2001) [Pubmed]
  7. Disorders of DNA replication and repair. Auerbach, A.D., Verlander, P.C. Curr. Opin. Pediatr. (1997) [Pubmed]
 
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