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Gene Review

T(1;13)70H  -  reciprocal translocation, Chr 1 and 13,...

Mus musculus

Synonyms: T70H
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Disease relevance of T(1;13)70H


High impact information on T(1;13)70H

  • BACKGROUND: Male mice, heterozygous for two semi-identical reciprocal translocations T(1;13)70H and T(1;13)1Wa are usually sterile [2].
  • At the 200 rad level, the mouse with normal karyotype was compared with the T(1;13)70H translocation heterozygote and the Ts(1(13))7OH tertiary trisomic of normal appearance [3].
  • Male meiotic behaviour and male and female litter size in mice with the T(2;8)26H and T(1;13)70H reciprocal translocations [4].
  • Three male and four female mouse single-sex chimeras derived from fusions of Rb(11.13)4Bnr T(1;13)70H homozygous embryos with +/+ embryos were caged with T(1;13)70H homozygotes of the opposite sex and followed through their reproductive lifespans [5].
  • Female mice of two age groups, 3--4 and 11--14 months old, homozygous for the T(1;13)70H reciprocal mouse translocation were used for cytological observations of bivalents (in primary oocytes) and metaphase II chromosomes (in secondary oocytes) [6].

Associations of T(1;13)70H with chemical compounds


Analytical, diagnostic and therapeutic context of T(1;13)70H

  • T(1;13)70H/+ translocation heretozygous mice were used for assessing heritability values for chiasma frequencies and the epididymal sperm count [8].


  1. Delayed meiotic development and correlated death of spermatocytes in male mice with chromosome abnormalities. Speed, R.M., de Boer, P. Cytogenet. Cell Genet. (1983) [Pubmed]
  2. Reduced oocyte activation and first cleavage rate after ICSI with spermatozoa from a sterile mouse chromosome mutant. Baart, E.B., van der Heijden, G.W., van der Hoeven, F.A., Bakker, R., Cooper, T.G., de Boer, P. Hum. Reprod. (2004) [Pubmed]
  3. Chromosomal radiosensitivity and karyotype in mice using cultured peripheral blood lymphocytes, and comparison with this system in man. De Boer, P., Van Buul, P.P., Van Beek, R., Van Der Hoeven, F.A., Natarajan, T. Mutat. Res. (1977) [Pubmed]
  4. Male meiotic behaviour and male and female litter size in mice with the T(2;8)26H and T(1;13)70H reciprocal translocations. de Boer, P. Genet. Res. (1976) [Pubmed]
  5. Transmission of gametes with normal or translocation chromosomes in male and female single-sex mouse chimeras. de Boer, P., van der Hoeven, F.A., Schöller, J.M. Cytogenet. Cell Genet. (1992) [Pubmed]
  6. The use of translocation-derived "marker-bivalents" for studying the origin of meiotic instability in female mice. de Boer, P., van der Hoeven, F.A. Cytogenet. Cell Genet. (1980) [Pubmed]
  7. Spermatogenic delay and increased chiasma frequency in T70H/+ male mice with hydroxyurea-Trenimon limited spermatocyte populations. Wauben-Penris, P.J., van Meel, G.P., de Boer, P. Can. J. Genet. Cytol. (1985) [Pubmed]
  8. Son-sire-regression based heritability estimates of chiasma frequency, using T70H mouse translocation heterozygotes, and the relation between univalence, chiasma frequency and sperm production. de Boer, P., van der Hoeven, F.A. Heredity (1977) [Pubmed]
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