Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Spsb4 - splA/ryanodine receptor domain and SOCS...

Mus musculus

Synonyms: D030068E18Rik, SPRY domain-containing SOCS box protein 4, SSB-4, Ssb4

Xing, Y. et al., Masters, S.L. et al., Takasato, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Spsb4

Quantitative analysis of SSB mRNA levels indicated that SSB-1, -2, and -3 were ubiquitously expressed; however, SSB-4 was only expressed at very low levels [1].
We also found groups of genes including SSB-4, Smarcd3, micro-Crystallin, TRB-2, which are not known to be expressed in the metanephric mesenchyme [2].

Anatomical context of Spsb4

Based on their tissue-restricted pattern of expression and apparent abundance in granulosa cells, we propose that SSB-1 and SSB-4 play key roles in regulating granulosa cell physiology [3].

Analytical, diagnostic and therapeutic context of Spsb4

Both SSB-1 and SSB-4 mRNA were detectable in mouse ovaries by Northern blotting of total and poly(A) + RNA, but were expressed in few other tissues [3].
Immunoblotting analysis revealed that SSB-1 protein was present in follicles at different stages of growth, and immunocytochemistry confirmed that SSB-1 and SSB-4 were detectable in granulosa cells of primary and subsequent stage follicles and that they were present in both mural and cumulus granulosa cells of antral follicles [3].

References

Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia. Masters, S.L., Palmer, K.R., Stevenson, W.S., Metcalf, D., Viney, E.M., Sprigg, N.S., Alexander, W.S., Nicola, N.A., Nicholson, S.E. Mol. Cell. Biol. (2005) [Pubmed]
Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato, M., Osafune, K., Matsumoto, Y., Kataoka, Y., Yoshida, N., Meguro, H., Aburatani, H., Asashima, M., Nishinakamura, R. Mech. Dev. (2004) [Pubmed]
Murine homologues of the Drosophila gustavus gene are expressed in ovarian granulosa cells. Xing, Y., Gosden, R., Lasko, P., Clarke, H. Reproduction (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP010197	Anopheles gambiae str. PEST
SPSB4	Bos taurus
spsb-1	Caenorhabditis elegans
spsb-2	Caenorhabditis elegans
SPSB4	Canis lupus familiaris
spsb4a	Danio rerio
gus	Drosophila melanogaster
SPSB4	Gallus gallus
SPSB4	Homo sapiens
SPSB4	Macaca mulatta
SPSB4	Pan troglodytes
Spsb4	Rattus norvegicus
spsb4	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.