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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tmprss4  -  transmembrane protease, serine 4

Mus musculus

Synonyms: Cap2, Channel-activating protease 2, Transmembrane protease serine 4, mCAP2
 
 
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High impact information on Tmprss4

  • Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1 [1].
  • Mouse channel activating proteases 1, 2, and 3 (mCAP1, mCAP2, and mCAP3) were described recently as regulators of the epithelial sodium channel (ENaC) [1].
  • Mutating the catalytic triad of mCAP2 not only abolished ENaC activation completely but also impeded cleavage of the protease [1].
  • In the present study, we have identified two additional membrane-bound serine proteases (mCAP2 and mCAP3) that are expressed in the same cell line [2].
 

Anatomical context of Tmprss4

  • Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes [2].

References

  1. Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1. Andreasen, D., Vuagniaux, G., Fowler-Jaeger, N., Hummler, E., Rossier, B.C. J. Am. Soc. Nephrol. (2006) [Pubmed]
  2. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes. Vuagniaux, G., Vallet, V., Jaeger, N.F., Hummler, E., Rossier, B.C. J. Gen. Physiol. (2002) [Pubmed]
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