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Gene Review

Kdm5a  -  lysine (K)-specific demethylase 5A

Mus musculus

Synonyms: AA409370, C76986, Histone demethylase JARID1A, Jarid1a, Jumonji/ARID domain-containing protein 1A, ...
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High impact information on Jarid1a

  • We have isolated a cDNA clone (RBP-2) for the protein (RBP-J kappa) which binds to immunoglobulin recombination signals with 23-base pair spacers (Matsunami, N., Hamaguchi, Y., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi, M., and Honjo, T. (1989) Nature 342, 934-937) [1].
  • RNase protection assays indicated that the RBP-2N type mRNA was produced in 10-20 times the quantity as RBP-2 mRNA [1].
  • The other was also a processed gene with a sequence exactly the same as that of RBP-2, except that this gene lacked the sequence corresponding to the first exon of the functional gene [1].
  • During further screening of a cDNA library from the same mouse pre-B cell line (38B9), we have isolated a second cDNA clone (RBP-2N) which differs from RBP-2 in its 5' sequence [1].
  • Among three mRNAs encoding putative recombinase proteins, RAG-1 and RAG-2 mRNAs were not expressed in any cell lines tested, while RBP-2 mRNA was expressed ubiquitously [2].

Biological context of Jarid1a


  1. Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene. Kawaichi, M., Oka, C., Shibayama, S., Koromilas, A.E., Matsunami, N., Hamaguchi, Y., Honjo, T. J. Biol. Chem. (1992) [Pubmed]
  2. Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines. Tashiro, K., Kinashi, T., Anderson, S.J., Lee, K.H., Tohyama, K., Ogawa, M., Takahashi, M., Kawaichi, M., Honjo, T. Immunol. Lett. (1991) [Pubmed]
  3. Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes. Hamaguchi, Y., Mastunami, N., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi, M., Honjo, T. Adv. Exp. Med. Biol. (1991) [Pubmed]
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