The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Nav1  -  neuron navigator 1

Mus musculus

Synonyms: 9530089B19, 9930003A20Rik, BC028801, C230080M11Rik, Kiaa1151, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Nav1

 

High impact information on Nav1

  • Although the functional role of Nav1 isoforms is primarily to form an action potential upstroke in excitable cells, recent biophysical studies indicate that some of the Nav1 isoforms can also influence subthreshold electrical activity through persistent or resurgent Na+ currents [2].
  • Na+ channels can be classified into two categories on the basis of their amino acid sequence, Nav1 isoforms currently comprising nine highly homologous clones and Nax that possesses structure diverging from Nav1, especially in several critical functional motifs [2].
  • During development, the channel subtypes expressed at the node undergo a transition from Nav1.2 to Nav1 [3].
  • Immunocytochemical localization of Nav1.1, beta(1), and beta(2) in adult heart sections showed that these subunits are expressed at the Z lines, as shown previously for Nav1 [4].

References

  1. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination. Rasband, M.N., Kagawa, T., Park, E.W., Ikenaka, K., Trimmer, J.S. J. Neurosci. Res. (2003) [Pubmed]
  2. Molecular diversity of structure and function of the voltage-gated Na+ channels. Ogata, N., Ohishi, Y. Jpn. J. Pharmacol. (2002) [Pubmed]
  3. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. Rios, J.C., Rubin, M., St Martin, M., Downey, R.T., Einheber, S., Rosenbluth, J., Levinson, S.R., Bhat, M., Salzer, J.L. J. Neurosci. (2003) [Pubmed]
  4. Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Dhar Malhotra, J., Chen, C., Rivolta, I., Abriel, H., Malhotra, R., Mattei, L.N., Brosius, F.C., Kass, R.S., Isom, L.L. Circulation (2001) [Pubmed]
 
WikiGenes - Universities