Disease relevance of Slc5a8

• Oxymatrine is one of the alkaloids extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.) with activities of anti-inflammation, inhibiting immune reaction, antivirus, protecting hepatocytes and antihepatic fibrosis [1].
• The effects of an ethanol extract of the plant Sophora flavescens Ait. on cardiac arrhythmias induced by coronary artery ligation in rats, and by aconitine infusion in mice, were studied [2].
• Orally in liquid diet administered procyanidin-containing extracts from Pinus pinaster Ait. decreased the croton oil-induced ear edema in mice or the compound 48/80-induced hind paw edema in rats to a statistically significant extent [3].

High impact information on Slc5a8

• Four isolates, A1, C1, D3, and F2, from the ethanol extract of the green leaves of Plumeria acuminata Ait, showed antimutagenic activity [4].
• Extracts from wild blueberry (Vaccinium angustifolium Ait.) were separated into proanthocyanidin-rich fractions using liquid vacuum and open column chromatography on Toyopearl and Sephadex LH-20, respectively [5].
• Slc5a8 had predominant expression sites in the distal half of the large bowel and in the most terminal ileum [6].
• The renal Slc5a8 immunoreactivity was localized only in the brush border of proximal tubules, not along the basolateral membrane [7].
• The present study examined the cellular localization of Slc5a8 in the murine gastrointestinal tract and kidney by in situ hybridization and immunohistochemistry [7].

Biological context of Slc5a8

• The action of solasodine, the steroid-structure alcaloid of Solanum laciniatum Ait., was studied on normal and pyretic body temperature of rats and mice [8].

Anatomical context of Slc5a8

• Thyroid follicular cells were immunoreactive for Slc5a8, with predominant labeling on the apical membrane [7].
• In the kidney, proximal tubules of both the cortex and the outer stripe of the outer medulla intensely expressed Slc5a8 mRNA, while the distal portions, including the loop of Henle, lacked the signals [7].
• No other organs, including the esophagus, stomach, liver, pancreas, and salivary glands contained any notable signals of Slc5a8 [7].
• The immunoreactivity of Slc5a8 was restricted to the striated border (the brush border) of enterocytes, and was not present in goblet cells, Paneth cells, or lamina propria cells [7].

Associations of Slc5a8 with chemical compounds

• These preliminary findings suggest that the ethanol extract of Sophora flavescens Ait. possesses antiarrhythmic activity [2].
• Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application [3].
• It has been shown in a previous work that the methanol extract obtained from the aerial part in blossom of Hypericum canariense L. and Hypericum glandulosum Ait. was active in the tetrabenazine and forced swimming test [9].
• Two novel lectins were purified from rhizomes of two sweet flag species, namely Acorus calamus (Linn.) and Acorus gramineus (Solandin Ait.) by affinity chromatography on mannose linked epoxy-activated Sepharose 6B [10].

References