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Gene Review:

Tdg - thymine DNA glycosylase

Mus musculus

Synonyms: C-JUN leucine zipper interactive protein JZA-3, E130317C12Rik, G/T mismatch-specific thymine DNA glycosylase, JZA-3, Jza1, ...

Um, S. et al., Sansom, O.J. et al., De Gregorio, L. et al.

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High impact information on Tdg

In vitro, TDG enhanced RXR and RXR/RAR binding to their response elements [1].
Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase [1].
In a yeast one-hybrid screen for proteins capable of interacting with native retinoic acid receptor (RAR), we have isolated the T:G mismatch-specific thymine-DNA glycosylase (TDG), which initiates the repair of T:G mismatches caused by spontaneous deamination of methylated cytosines [1].
MBD4 was originally identified through its methyl binding domain, but has more recently been characterized as a thymine DNA glycosylase that interacts with the mismatch repair (MMR) protein MLH1 [2].
Genetic mapping of thymine DNA glycosylase (Tdg) gene and of one pseudogene in the mouse [3].

References

Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase. Um, S., Harbers, M., Benecke, A., Pierrat, B., Losson, R., Chambon, P. J. Biol. Chem. (1998) [Pubmed]
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Sansom, O.J., Zabkiewicz, J., Bishop, S.M., Guy, J., Bird, A., Clarke, A.R. Oncogene (2003) [Pubmed]
Genetic mapping of thymine DNA glycosylase (Tdg) gene and of one pseudogene in the mouse. De Gregorio, L., Gallinari, P., Gariboldi, M., Manenti, G., Pierotti, M.A., Jiricny, J., Dragani, T.A. Mamm. Genome (1996) [Pubmed]

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TDG	Bos taurus
TDG	Canis lupus familiaris
tdg.1	Danio rerio
TDG	Gallus gallus
TDG	Homo sapiens
TDG	Macaca mulatta
Gm5806	Mus musculus
TDG	Pan troglodytes
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tdg	Xenopus (Silurana) tropicalis

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