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Trim25  -  tripartite motif-containing 25

Mus musculus

Synonyms: AA960166, AL022677, E3 ubiquitin/ISG15 ligase TRIM25, EFP, Efp, ...
 
 
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Disease relevance of Trim25

  • We demonstrate that tumour growth of breast cancer MCF7 cells implanted in female athymic mice is reduced by treatment with antisense Efp oligonucleotide [1].
  • Replicate differences were studied in lines of mice selected at 12 weeks of age for high (HF1, HF2) or low (LF1, LF2) right epididymal fat pad weight as a percentage of body weight (%EFP); for high (HL1, HL2) or low (LL1, LL2) hind carcass weight as a percentage of body weight (%HC); and randomly (RC1, RC2) [2].
 

High impact information on Trim25

  • Efp is predominantly expressed in various female organs as well as in breast cancers, and is thought to be essential for oestrogen-dependent cell proliferation and organ development Efp-disrupted mice display underdeveloped uteri and reduced oestrogen responsiveness [1].
  • These data provide an insight into the cell-cycle machinery and tumorigenesis of breast cancer by identifying 14-3-3 sigma as a target for proteolysis by Efp, leading to cell proliferation [1].
  • Loss of Efp function in mouse embryonic fibroblasts results in an accumulation of 14-3-3 sigma, which is responsible for reduced cell growth [1].
  • Although efp homozygous mice were viable and fertile in both sexes, the uterus that expressed abundant estrogen receptor alpha exhibited significant underdevelopment [3].
  • The biological roles of estrogen-responsive finger protein (efp) in vivo were evaluated in mice carrying a loss-of-function mutation in efp by gene-targeted mutagenesis [3].
 

Chemical compound and disease context of Trim25

  • Given that ER is over-expressed in a large proportion of breast cancers, we reasoned that EFP may play a role in mediating the estrogen-dependent progression of breast cancer [4].
 

Biological context of Trim25

  • The efp protein has a RING finger, a variant type of zinc finger motif, B1 box, and B2 box, each having a pair of zinc fingers, present in a family of apparent DNA-binding proteins [5].
  • Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family [5].
  • Here, we have characterized the basal promoter region of the mouse efp gene [6].
  • We have previously identified an estrogen-responsive gene, efp (estrogen-responsive finger protein), by genomic binding-site cloning method [7].
  • Significant heterosis in replicate crosses within selection treatments was found for %HC in HL, LL, and LF and for %EFP in HF [2].
 

Anatomical context of Trim25

  • However, on days 3 and 4, the accumulation of Efp mRNA occurred in stromal cells, in addition to its presence in the epithelium [8].
  • However, on days 6-8, Efp mRNA was localized throughout the deciduum [8].
  • Increased levels of EFP in lactating breast and the reduction in malignancy suggest a role for EFP in promoting mammary gland differentiation [4].
  • We raised anti-sera to EFP and show that EFP is present in the cytoplasm in mammary cell lines and epithelial cells of normal breast tissue [4].
  • Lymphocytes from colonized or intravenously challenged mice responded to a recombinant C. albicans enolase fusion protein (EFP) [9].
 

Associations of Trim25 with chemical compounds

 

Other interactions of Trim25

 

Analytical, diagnostic and therapeutic context of Trim25

  • However, results of in situ hybridization showed cell-specific distribution of Efp mRNA in the periimplantation uterus in a temporal manner [8].
  • Furthermore, EFP is present in cell culture medium, suggesting that it may be secreted [4].
  • Immunohistochemistry of paraffin-embedded breast biopsy specimens showed significantly greater levels of EFP in lactating breast and fibroadenomata compared to normal breast (p<0.001 and p = 0.001, respectively), which is likely to be a result of estrogen responsiveness [4].
  • An electrophoretic mobility shift assay using Jyg-Mc(B) nuclear extracts shows that a transcription factor, USF-1 binds to the E-box in the mouse efp promoter [6].

References

  1. Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S. Nature (2002) [Pubmed]
  2. Replicate differences in lines of mice selected for body composition. Eisen, E.J., Pomp, D. Genome (1990) [Pubmed]
  3. Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha. Orimo, A., Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, J., Hiroi, H., Shimizu, Y., Suzuki, M., Noda, T., Muramatsu, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Analysis of estrogen-responsive finger protein expression in benign and malignant human breast. Thomson, S.D., Ali, S., Pickles, L., Taylor, J., Pace, P.E., Lymboura, M., Shousha, S., Coombes, R.C. Int. J. Cancer (2001) [Pubmed]
  5. Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T., Muramatsu, M. Genomics (1995) [Pubmed]
  6. Promoter analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promoter contains an E-box that is also conserved in human. Ikeda, K., Inoue, S., Orimo, A., Tsutsumi, K., Muramatsu, M. Gene (1998) [Pubmed]
  7. Molecular cloning of rat efp: expression and regulation in primary osteoblasts. Inoue, S., Urano, T., Ogawa, S., Saito, T., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. Uterine preparation for implantation in the mouse is associated with coordinate expression of estrogen-responsive finger protein and estrogen receptor. Das, N., Wang, J., Dey, S.K. Mol. Reprod. Dev. (1997) [Pubmed]
  9. Humoral and cellular immune responses to enolase after alimentary tract colonization or intravenous immunization with Candida albicans. Sundstrom, P., Jensen, J., Balish, E. J. Infect. Dis. (1994) [Pubmed]
  10. Molecular cloning, structure, and expression of mouse estrogen-responsive finger protein Efp. Co-localization with estrogen receptor mRNA in target organs. Orimo, A., Inoue, S., Ikeda, K., Noji, S., Muramatsu, M. J. Biol. Chem. (1995) [Pubmed]
  11. Cell differentiation in human anagen hair and hair follicles studied with anti-hair keratin monoclonal antibodies. Ito, M., Tazawa, T., Shimizu, N., Ito, K., Katsuumi, K., Sato, Y., Hashimoto, K. J. Invest. Dermatol. (1986) [Pubmed]
  12. Stage-specific expression of estrogen receptor subtypes and estrogen responsive finger protein in preimplantational mouse embryos. Hiroi, H., Momoeda, M., Inoue, S., Tsuchiya, F., Matsumi, H., Tsutsumi, O., Muramatsu, M., Taketani, Y. Endocr. J. (1999) [Pubmed]
 
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