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Gene Review

Cd300a  -  CD300A antigen

Mus musculus

Synonyms: B230315M08Rik, CD300 antigen-like family member A, CLM-8, CMRF35-like molecule 8, Clm8, ...
 
 
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Disease relevance of Cd300a

  • To evaluate the role of IRp60 in regulation of allergic responses in vivo, a murine model of allergic peritonitis was used in which the murine homolog of IRp60, LMIR1, was neutralized in BALB/c mice by mAbs [1].
 

High impact information on Cd300a

  • The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs) [2].
  • We named these molecules leukocyte mono-Ig-like receptor1 and 2 (LMIR1 and 2) [2].
  • Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells [2].

References

  1. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. Bachelet, I., Munitz, A., Moretta, A., Moretta, L., Levi-Schaffer, F. J. Immunol. (2005) [Pubmed]
  2. Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Kumagai, H., Oki, T., Tamitsu, K., Feng, S.Z., Ono, M., Nakajima, H., Bao, Y.C., Kawakami, Y., Nagayoshi, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kawakami, T., Kitamura, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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