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Tgm3  -  transglutaminase 3, E polypeptide

Mus musculus

Synonyms: AI893889, Protein-glutamine gamma-glutamyltransferase E, TG E, TG(E), TGE, ...
 
 
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High impact information on Tgm3

  • We demonstrate that the addition of the mouse QK isoform-6 (QKI-6) protein to a mammalian cell line that lacks QKI-6 can confer regulation on reporter and GLI1 mRNAs in a TGE-specific manner, and reduction of QKI-6 activity with siRNA disrupts translational control [1].
  • The above findings suggest that the expression of TGM3 plays a important role in the epidermis differentiation in embryogenesis [2].
  • Changes in EGF and TGE-beta receptor expression reflects differentiation of rat malignant oral keratinocytes [3].
 

Analytical, diagnostic and therapeutic context of Tgm3

  • In the present study, we detected the expression of TGM3 in the mouse embryo using RT-PCR [2].
  • Then we determined the spatial and temporal expression pattern of TGM3 in the skin and other organs by in situ hybridization [2].
  • We show by immunoprecipitation that QKI-6 antibody specifically co-purifies TGE-containing mRNAs in ribonucleoproteins [1].

References

  1. STAR proteins quaking-6 and GLD-1 regulate translation of the homologues GLI1 and tra-1 through a conserved RNA 3'UTR-based mechanism. Lakiza, O., Frater, L., Yoo, Y., Villavicencio, E., Walterhouse, D., Goodwin, E.B., Iannaccone, P. Dev. Biol. (2005) [Pubmed]
  2. Transglutaminase 3 expression in C57BL/6J mouse embryo epidermis and the correlation with its differentiation. Zhang, J., Zhi, H.Y., Ding, F., Luo, A.P., Liu, Z.H. Cell Res. (2005) [Pubmed]
  3. Changes in EGF and TGE-beta receptor expression reflects differentiation of rat malignant oral keratinocytes. Game, S., Stone, A., Scully, C., Prime, S. Biochem. Soc. Trans. (1991) [Pubmed]
 
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