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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Thbs4  -  thrombospondin 4

Mus musculus

Synonyms: TSP-4, TSP4, Thrombospondin-4, Tsp4
 
 
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High impact information on Thbs4

  • This closely coincided with the expression of thrombospondin-4 in adjacent prospective tendon mesenchyme, suggesting that these two compartments may constitute a functional unit involved in muscle morphogenesis [1].
  • However, the means by which TSP-4 promotes neurite outgrowth in the developing eye is unclear [2].
  • These results support a model where TSP-4 acts as an organizer of adhesive and axon outgrowth-promoting molecules in the ECM to optimize retinal ganglion cell responses [2].
 

Anatomical context of Thbs4

  • Here we show that TSP-4 is present at the appropriate time in development and displays a localization pattern within the developing mouse retina consistent with a role in retinal ganglion cell (RGC) neurite outgrowth [2].
 

Associations of Thbs4 with chemical compounds

  • Thrombospondin-4 (TSP-4), a large pentameric glycoprotein of the extracellular matrix, has been described as a neurite outgrowth-promoting molecule [2].

References

  1. Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. Baumeister, A., Arber, S., Caroni, P. J. Cell Biol. (1997) [Pubmed]
  2. Thrombospondin-4 and matrix three-dimensionality in axon outgrowth and adhesion in the developing retina. Dunkle, E.T., Zaucke, F., Clegg, D.O. Exp. Eye Res. (2007) [Pubmed]
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