The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tjp1  -  tight junction protein 1

Mus musculus

Synonyms: Tight junction protein 1, Tight junction protein ZO-1, ZO-1, ZO1, Zo1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tjp1


High impact information on Tjp1

  • Furthermore, immunoreactivity to SSeCKS gradually increased during the BBB maturation period, and SSeCKS-expressing astrocytes closely interacted with zonula occludens (ZO)-1-expressing blood vessels in vivo [6].
  • Leaky epithelium in gammadelta(+) iIEL-deficient mice was associated with the absence of phosphorylation of serine residues of occludin and lack of claudin 3 and zona occludens-1 proteins in TJ complexes [7].
  • In vitro, Giardia increased permeability and phosphorylation of MLC and reorganized F-actin and ZO-1 [8].
  • CONCLUSIONS: Disruption of small intestinal barrier function is T cell independent, disappears on parasite clearance, and correlates with reorganization of cytoskeletal F-actin and tight junctional ZO-1 in an MLCK-dependent fashion [8].
  • Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive [9].

Biological context of Tjp1


Anatomical context of Tjp1


Associations of Tjp1 with chemical compounds


Physical interactions of Tjp1


Other interactions of Tjp1

  • ZO-1 immunogold electron microscopy showed unlabeled tight junctions and the presence of gold particles scattered in the endothelial cytoplasm in the mdx mice, whereas ZO-1 gold particles were exclusively located at the endothelial tight junctions in the controls [25].
  • Based on the presence of sequence corresponding to a putative PDZ binding motif in Cx36, we investigated anatomical relationships and molecular association of Cx36 with ZO-1 [21].
  • Double-labeled immunostaining demonstrated that ZO-1-positive staining was significantly decreased on the microvessel wall in the VEGF plus Ang-2-treated group [26].
  • The changes in MMP-9 activity paralleled the reduced ZO-1 expression in the VEGF plus Ang-2-treated group compared with the other 5 groups (P<0.05) [26].
  • We have shown previously that individual components of the tight junction assemble in a temporal sequence, with membrane assembly of the cytoplasmic plaque protein ZO-1 occurring 12 hours before that of cingulin [15].

Analytical, diagnostic and therapeutic context of Tjp1


  1. Thalidomide treatment reduces the alteration of paracellular barrier function in mice ileum during experimental colitis. Mazzon, E., Cuzzocrea, S. Shock (2006) [Pubmed]
  2. HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation. Pu, H., Tian, J., Andras, I.E., Hayashi, K., Flora, G., Hennig, B., Toborek, M. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  3. Downregulation of matrix metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain injury. Mori, T., Wang, X., Aoki, T., Lo, E.H. J. Neurotrauma (2002) [Pubmed]
  4. Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice. Han, X., Fink, M.P., Uchiyama, T., Yang, R., Delude, R.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  5. Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types. Howarth, A.G., Hughes, M.R., Stevenson, B.R. Am. J. Physiol. (1992) [Pubmed]
  6. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Lee, S.W., Kim, W.J., Choi, Y.K., Song, H.S., Son, M.J., Gelman, I.H., Kim, Y.J., Kim, K.W. Nat. Med. (2003) [Pubmed]
  7. Intraepithelial gammadelta(+) Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection. Dalton, J.E., Cruickshank, S.M., Egan, C.E., Mears, R., Newton, D.J., Andrew, E.M., Lawrence, B., Howell, G., Else, K.J., Gubbels, M.J., Striepen, B., Smith, J.E., White, S.J., Carding, S.R. Gastroenterology (2006) [Pubmed]
  8. Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Scott, K.G., Meddings, J.B., Kirk, D.R., Lees-Miller, S.P., Buret, A.G. Gastroenterology (2002) [Pubmed]
  9. Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. Miyamoto, T., Morita, K., Takemoto, D., Takeuchi, K., Kitano, Y., Miyakawa, T., Nakayama, K., Okamura, Y., Sasaki, H., Miyachi, Y., Furuse, M., Tsukita, S. J. Cell Biol. (2005) [Pubmed]
  10. Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7. Mohandas, T.K., Chen, X.N., Rowe, L.B., Birkenmeier, E.H., Fanning, A.S., Anderson, J.M., Korenberg, J.R. Genomics (1995) [Pubmed]
  11. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Penes, M.C., Li, X., Nagy, J.I. Eur. J. Neurosci. (2005) [Pubmed]
  12. Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. Murata, M., Kojima, T., Yamamoto, T., Go, M., Takano, K., Chiba, H., Tokino, T., Sawada, N. Cell Tissue Res. (2005) [Pubmed]
  13. Aberrant retinal tight junction and adherens junction protein expression in an animal model of autosomal dominant Retinitis pigmentosa: the Rho(-/-) mouse. Campbell, M., Humphries, M., Kennan, A., Kenna, P., Humphries, P., Brankin, B. Exp. Eye Res. (2006) [Pubmed]
  14. Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction. Demaude, J., Salvador-Cartier, C., Fioramonti, J., Ferrier, L., Bueno, L. Gut (2006) [Pubmed]
  15. Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform. Sheth, B., Fesenko, I., Collins, J.E., Moran, B., Wild, A.E., Anderson, J.M., Fleming, T.P. Development (1997) [Pubmed]
  16. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. Umeda, K., Matsui, T., Nakayama, M., Furuse, K., Sasaki, H., Furuse, M., Tsukita, S. J. Biol. Chem. (2004) [Pubmed]
  17. Zonula occludens-1 and E-cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization. Paria, B.C., Zhao, X., Das, S.K., Dey, S.K., Yoshinaga, K. Dev. Biol. (1999) [Pubmed]
  18. Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: potential mechanism of tight junction regulation. Schmidt, A., Utepbergenov, D.I., Mueller, S.L., Beyermann, M., Schneider-Mergener, J., Krause, G., Blasig, I.E. Cell. Mol. Life Sci. (2004) [Pubmed]
  19. High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1). Rash, J.E., Pereda, A., Kamasawa, N., Furman, C.S., Yasumura, T., Davidson, K.G., Dudek, F.E., Olson, C., Li, X., Nagy, J.I. J. Neurocytol. (2004) [Pubmed]
  20. Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro. Zettl, K.S., Sjaastad, M.D., Riskin, P.M., Parry, G., Machen, T.E., Firestone, G.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1. Li, X., Olson, C., Lu, S., Kamasawa, N., Yasumura, T., Rash, J.E., Nagy, J.I. Eur. J. Neurosci. (2004) [Pubmed]
  22. The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. Müller, S.L., Portwich, M., Schmidt, A., Utepbergenov, D.I., Huber, O., Blasig, I.E., Krause, G. J. Biol. Chem. (2005) [Pubmed]
  23. Characterization of the association of connexins and ZO-1 in the lens. Nielsen, P.A., Baruch, A., Giepmans, B.N., Kumar, N.M. Cell Commun. Adhes. (2001) [Pubmed]
  24. Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells. Meyer, T.N., Schwesinger, C., Denker, B.M. J. Biol. Chem. (2002) [Pubmed]
  25. Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Nico, B., Frigeri, A., Nicchia, G.P., Corsi, P., Ribatti, D., Quondamatteo, F., Herken, R., Girolamo, F., Marzullo, A., Svelto, M., Roncali, L. Glia (2003) [Pubmed]
  26. Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain. Zhu, Y., Lee, C., Shen, F., Du, R., Young, W.L., Yang, G.Y. Stroke (2005) [Pubmed]
  27. Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus. Inagaki, M., Irie, K., Deguchi-Tawarada, M., Ikeda, W., Ohtsuka, T., Takeuchi, M., Takai, Y. J. Comp. Neurol. (2003) [Pubmed]
WikiGenes - Universities