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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Trpc3  -  transient receptor potential cation...

Mus musculus

Synonyms: Mwk, Receptor-activated cation channel TRP3, Short transient receptor potential channel 3, TRP-3, Transient receptor protein 3, ...
 
 
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High impact information on Trpc3

  • [Trp3, Arg5]-ghrelin(1-5) stimulates growth hormone secretion and food intake via growth hormone secretagogue (GHS) receptor [1].
  • We found that [Trp3, Arg5]-ghrelin(1-5) (GSWFR), a novel pentapeptide composed of all L-amino acids, had affinity for the GHS receptor (IC50 = 10 microM) [1].
  • Replacements at two other positions (His-2 and Trp-3) completely negated immunocastration activity [2].
  • Mtrp-1 mRNA was expressed widely throughout the gray matters, while the expression for Mtrp-3 was dominant in the cerebellar Purkinje cells, the olfactory mitral cells and the striatal large-sized intrinsic neurons [3].

References

  1. [Trp3, Arg5]-ghrelin(1-5) stimulates growth hormone secretion and food intake via growth hormone secretagogue (GHS) receptor. Ohinata, K., Kobayashi, K., Yoshikawa, M. Peptides (2006) [Pubmed]
  2. The role of the individual amino acids of a GnRH-tandem-dimer peptide used as an antigen for immunocastration of male piglets determined with systematic alanine replacements. Turkstra, J.A., Oonk, H.B., Schaaper, W.M., Meloen, R.H. Vaccine (2001) [Pubmed]
  3. Differential localization of mRNAs for mammalian trps, presumptive capacitative calcium entry channels, in the adult mouse brain. Otsuka, Y., Sakagami, H., Owada, Y., Kondo, H. Tohoku J. Exp. Med. (1998) [Pubmed]
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