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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Trpc4  -  transient receptor potential cation...

Mus musculus

Synonyms: CCE1, Capacitative calcium entry channel Trp4, Receptor-activated cation channel TRP4, STRPC4, Short transient receptor potential channel 4, ...
 
 
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High impact information on Trpc4

  • Here we describe a store-operated Ca2+ current in vascular endothelium and show that endothelial cells of mice deficient in TRP4 (also known as CCE1) lack this current [1].
  • The unexpected absence of the transient receptor potential channel, Trpc4, from Lyn(-/-) BMMCs may additionally contribute to their altered signaling properties [2].
  • Asterisks indicate post-translational modifications (left to right): proteolytic cleavage at the N-terminus; hydroxylation of Pro3; epimerization of Trp4; bromination of Trp7, and C-terminal amidation [3].

References

  1. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Freichel, M., Suh, S.H., Pfeifer, A., Schweig, U., Trost, C., Weissgerber, P., Biel, M., Philipp, S., Freise, D., Droogmans, G., Hofmann, F., Flockerzi, V., Nilius, B. Nat. Cell Biol. (2001) [Pubmed]
  2. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. Hernandez-Hansen, V., Smith, A.J., Surviladze, Z., Chigaev, A., Mazel, T., Kalesnikoff, J., Lowell, C.A., Krystal, G., Sklar, L.A., Wilson, B.S., Oliver, J.M. J. Immunol. (2004) [Pubmed]
  3. Bromocontryphan: post-translational bromination of tryptophan. Jimenez, E.C., Craig, A.G., Watkins, M., Hillyard, D.R., Gray, W.R., Gulyas, J., Rivier, J.E., Cruz, L.J., Olivera, B.M. Biochemistry (1997) [Pubmed]
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