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Gene Review

Ttc3  -  tetratricopeptide repeat domain 3

Mus musculus

Synonyms: 2610202A04Rik, AA409221, D16Ium21, D16Ium21e, E3 ubiquitin-protein ligase TTC3, ...
 
 
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Disease relevance of Ttc3

  • Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1 [1].
 

High impact information on Ttc3

  • The gene was mapped to mouse chromosome 16C3.3-4, consistent with the location of DCR, and encodes 1,979 amino acid residues with 76% identity to TPRD [2].
 

Biological context of Ttc3

  • Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome [2].

References

  1. Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1. Lopes, C., Rachidi, M., Gassanova, S., Sinet, P.M., Delabar, J.M. Mech. Dev. (1999) [Pubmed]
  2. Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome. Tsukahara, F., Urakawa, I., Hattori, M., Hirai, M., Ohba, K., Yoshioka, T., Sakaki, Y., Muraki, T. J. Biochem. (1998) [Pubmed]
 
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