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Ugt2b5  -  UDP glucuronosyltransferase 2 family,...

Mus musculus

Synonyms: AI118071, M-1, UDP-glucuronosyltransferase 2B17, UDP-glucuronosyltransferase 2B5, UDPGT 2B5, ...
 
 
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Disease relevance of Ugt2b5

  • However, in rabbit reticulocyte lysates these same transcripts are translated from IC1 as well as from IC2, and transcripts in which m1 RNA is preceded by long sequences of encephalomyocarditis virus RNA (from the T7 polymerase-controlled pTM1 vector) are translated exclusively from IC1 [1].
  • Thus, preferential accumulation and prolonged retention of 8-OHQ in RIF tumors may be caused by a combination of factors: a) high tumor beta-glucuronidase activity, b) selective tumor acidification during hyperglycemia, c) low tumor UDPGT activity, and d) other factors, such as tumor blood flow [2].
  • Hyperthermia had only a modest effects on UDPGT activity: a heat dose of 30 min at 45 degrees C reduced activity less than 60% [2].
  • These results suggest that the muscarinic receptors encoded by the transfected m1 gene in the cTB10 cells are of the M1 type and are coupled to the hydrolysis of inositol lipids, possibly via a pertussis toxin sensitive G protein [3].
  • Low correlation coefficients were found for the maximal responses of muscarinic agonists in rat ganglion and cloned m1 receptors (0.53) and in guinea-pig ileum and cloned m3 receptors (0.36) [4].
 

High impact information on Ugt2b5

  • However, the robust suppression of the M-current potassium channel activity evoked by muscarinic agonists in sympathetic ganglion neurons is completely lost in m1 mutant mice [5].
  • 1. Using equivalent short circuit current (ISC) measurements we examined the effect of extracellular ATP on transepithelial ion transport in M-1 mouse cortical collecting duct cells [6].
  • Injection of oocytes expressing either receptor isoform with specific antisense oligonucleotides complementary to either m1 or m3 muscarinic receptors (from mouse) showed receptor loss at approximately the same rate as that calculated from experiments with CHX [7].
  • The expression of cloned m1 muscarinic receptors, however, was not affected by tunicamycin, suggesting that glycosylation is not a general prerequisite for the functional expression of muscarinic receptors [7].
  • A9 L cells stable transfected with m1 muscarinic receptors were stimulated with the full agonist carbachol and with the partial agonist pilocarpine [8].
 

Biological context of Ugt2b5

  • The altered pattern of AHH and UDPGT in transformed epithelial cell lines is consistent with toxin-resistance of initiated cells, similar to the toxin-resistance phenotype characterized in liver after initiation of hepatocarcinogenesis [9].
  • We studied the relationship between the M1 muscarinic receptor density and the receptor-mediated hydrolysis of inositol lipids in cloned murine fibroblast B82 cells which were transfected with the m1 muscarinic receptor gene [10].
  • Because monocytes and macrophages are a key component of innate immunity, we hypothesized that early polarization of distinct activation programs in circulating monocytes that culminates in the emergence of either classically (M1) or alternatively (M2) activated monocytes may underlie the observed susceptibility or resistance to infection [11].
  • These findings support a role for presynaptic m1 mAChRs in modulation of synaptic transmission in CA1, but indicate that other muscarinic receptor subtypes, such as M2, are also involved in suppression of synaptic potentials [12].
  • The m1 (%PI) SAR were distinctly different from the analgesia and the salivation SAR, suggesting that analgesia is mediated by neither m1 nor M3 muscarinic receptors [13].
 

Anatomical context of Ugt2b5

 

Associations of Ugt2b5 with chemical compounds

  • Unique among the compounds, PhSCA reduced the transcript levels of GstA, and the 1.6 kb transcript of Gpx although only when given i.p. Neither l-selenocystine nor SCA affected the level of any transcript and no compound altered the amount of Ugt2b5 mRNA [16].
  • After topical application of Aroclor 1254 to the skin UDPGT activities towards 1-naphthol, 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol were increased 3-fold and AHH activity was increased 15-fold [9].
  • UDP-glucuronosyltransferase (UDPGT) was studied immunohistochemically in hepatic foci and nodules of N-nitrosomorpholine-treated mice [17].
  • In contrast, dibutyryl cAMP caused a significant time-dependent decrease in the level of m4-mAChR mRNA in NCB-20 and NG108-15 cells as well as m1-mAChR mRNA in NCB-20 cells [18].
  • 1. Isozymes of the cytochromes P-450, UDP-glucuronosyl transferases (UDPGT) and glutathione S-transferases appear to be differentially inducible by prototype inducers, such as 3-methylcholanthrene (MC), phenobarbital, pregnenolone 16 alpha-carbonitrile and clofibrate [19].
 

Other interactions of Ugt2b5

  • The major phenotype observed in rat hepatocarcinogenesis models (UDPGT-positive/G6Pase-negative foci) was not detectable in the mouse model [17].
  • Results show that D3 causes a 150% elevation of GSHT activity and the maintenance of normal, near-control UDPGT activity and cytochrome P-450 content, up to almost 30 days following tumor transplantation, along with bringing about a twofold increase in survival of the host mice [20].
 

Analytical, diagnostic and therapeutic context of Ugt2b5

References

  1. Translation of reovirus RNA species m1 can initiate at either of the first two in-frame initiation codons. Roner, M.R., Roner, L.A., Joklik, W.K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Tumor-targeted delivery of 8-hydroxyquinoline. Monson, T.P., Henle, K.J., Nagle, W.A., Mansouri, A. Int. J. Radiat. Oncol. Biol. Phys. (1991) [Pubmed]
  3. Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells. Mei, L., Lai, J., Roeske, W.R., Fraser, C.M., Venter, J.C., Yamamura, H.I. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  4. Pharmacological properties of cloned muscarinic receptors expressed in A9 L cells; comparison with in vitro models. Boddeke, H.W., Buttini, M. Eur. J. Pharmacol. (1991) [Pubmed]
  5. Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Hamilton, S.E., Loose, M.D., Qi, M., Levey, A.I., Hille, B., McKnight, G.S., Idzerda, R.L., Nathanson, N.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. ATP stimulates Cl- secretion and reduces amiloride-sensitive Na+ absorption in M-1 mouse cortical collecting duct cells. Cuffe, J.E., Bielfeld-Ackermann, A., Thomas, J., Leipziger, J., Korbmacher, C. J. Physiol. (Lond.) (2000) [Pubmed]
  7. Kinetics of the functional loss of different muscarinic receptor isoforms in Xenopus oocytes. Matus-Leibovitch, N., Mengod, G., Oron, Y. Biochem. J. (1992) [Pubmed]
  8. Comparison of second-messenger responses to muscarinic receptor stimulation in M1-transfected A9 L cells. Baumgold, J., Dyer, K., Falcone, J.F., Bymaster, F.P. Cell. Signal. (1995) [Pubmed]
  9. Induction of UDP-glucuronyltransferase and arylhydrocarbon hydroxylase activity in mouse skin and in normal and transformed skin cells in culture. Lilienblum, W., Irmscher, G., Fusenig, N.E., Bock, K.W. Biochem. Pharmacol. (1986) [Pubmed]
  10. The relationship between agonist states of the M1 muscarinic receptor and the hydrolysis of inositol lipids in transfected murine fibroblast cells (B82) expressing different receptor densities. Mei, L., Lai, J., Yamamura, H.I., Roeske, W.R. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  11. Infection-induced modulation of m1 and m2 phenotypes in circulating monocytes: role in immune monitoring and early prognosis of sepsis. Mehta, A., Brewington, R., Chatterji, M., Zoubine, M., Kinasewitz, G.T., Peer, G.T., Chang, A.C., Taylor, F.B., Shnyra, A. Shock (2004) [Pubmed]
  12. Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABA(B) receptors. Kremin, T., Gerber, D., Giocomo, L.M., Huang, S.Y., Tonegawa, S., Hasselmo, M.E. Neurobiology of learning and memory. (2006) [Pubmed]
  13. Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs. Sauerberg, P., Olesen, P.H., Sheardown, M.J., Suzdak, P.D., Shannon, H.E., Bymaster, F.P., Calligaro, D.O., Mitch, C.H., Ward, J.S., Swedberg, M.D. Life Sci. (1995) [Pubmed]
  14. Muscarinic receptor profiles of mouse brain astrocytes in culture vary with their tissue of origin but differ from those of neurons. André, C., Dos Santos, G., Koulakoff, A. Eur. J. Neurosci. (1994) [Pubmed]
  15. The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes. Ismail, S., Back, D.J., Edwards, G. Biochem. Pharmacol. (1992) [Pubmed]
  16. Acute effects of novel selenazolidines on murine chemoprotective enzymes. El-Sayed, W., Aboul-Fadl, T., Lamb, J.G., Roberts, J.C., Franklin, M.R. Chem. Biol. Interact. (2006) [Pubmed]
  17. Heterogeneous alterations of UDP-glucuronosyltransferases in mouse hepatic foci. Bock, K.W., Kobusch, A.B., Fischer, G. J. Cancer Res. Clin. Oncol. (1989) [Pubmed]
  18. Differential effects of butyrate and dibutyryl cAMP on mRNA levels of muscarinic acetylcholine receptor subtypes expressed in neurohybrid cell lines. Fukamauchi, F., Mataga, N., Wang, Y.J., Chuang, D.M. Neurosci. Lett. (1996) [Pubmed]
  19. Induction of drug-metabolizing enzymes by xenobiotics. Bock, K.W., Lipp, H.P., Bock-Hennig, B.S. Xenobiotica (1990) [Pubmed]
  20. Role of vitamin D3 on the activity patterns of hepatic drug metabolizing enzymes in transplantable murine lymphoma. Sardar, S., Chatterjee, M., Ghosh, S., Roy, K. Cancer Invest. (1996) [Pubmed]
 
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