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Gene Review

Uncx  -  UNC homeobox

Mus musculus

Synonyms: Chx4, Homeobox protein Uncx4.1, Homeobox protein unc-4 homolog, Uncx4.1
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High impact information on Uncx4.1


Biological context of Uncx4.1

  • The data show a selective role of Uncx4.1 in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions [4].

Anatomical context of Uncx4.1


Other interactions of Uncx4.1

  • However, the staining for Uncx4.1 revealed that, in the N-cadherin mutants, each somite tended to be cleaved at the border between the Uncx4 [7].
  • Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse [8].


  1. Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. Nomura-Kitabayashi, A., Takahashi, Y., Kitajima, S., Inoue, T., Takeda, H., Saga, Y. Development (2002) [Pubmed]
  2. Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9. Mansouri, A., Voss, A.K., Thomas, T., Yokota, Y., Gruss, P. Development (2000) [Pubmed]
  3. The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Leitges, M., Neidhardt, L., Haenig, B., Herrmann, B.G., Kispert, A. Development (2000) [Pubmed]
  4. Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1. Asbreuk, C.H., van Doorninck, J.H., Mansouri, A., Smidt, M.P., Burbach, J.P. J. Mol. Endocrinol. (2006) [Pubmed]
  5. Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. Schubert, F.R., Tremblay, P., Mansouri, A., Faisst, A.M., Kammandel, B., Lumsden, A., Gruss, P., Dietrich, S. Dev. Dyn. (2001) [Pubmed]
  6. Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system. Mansouri, A., Yokota, Y., Wehr, R., Copeland, N.G., Jenkins, N.A., Gruss, P. Dev. Dyn. (1997) [Pubmed]
  7. Adhesive subdivisions intrinsic to the epithelial somites. Horikawa, K., Radice, G., Takeichi, M., Chisaka, O. Dev. Biol. (1999) [Pubmed]
  8. Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse. Okano, S., Asano, A., Sasaki, N., Kon, Y., Watanabe, T., Agui, T. Jpn. J. Vet. Res. (2005) [Pubmed]
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