High impact information on Uncx4.1

• The defects in RC polarity were determined by the altered expressions of Uncx4.1 and Dll1 in the segmented somites and presomitic mesoderm, respectively [1].
• Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9 [2].
• Histological and marker analysis revealed that Uncx4.1 is not necessary for somite segmentation [2].
• The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column [3].
• Our results further indicate that Uncx4.1 may be involved in the differential cell adhesion properties of the somite [2].

Biological context of Uncx4.1

• The data show a selective role of Uncx4.1 in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions [4].

Anatomical context of Uncx4.1

• Moreover, rostrocaudal somite pattern and somitic boundaries are disturbed in Splotch as monitored by the expression of Uncx4.1 and Lunatic fringe [5].
• In situ hybridization analysis revealed that Uncx4.1 is expressed in the paraxial mesoderm, in the developing kidney, and central nervous system [6].
• In the central nervous system, Uncx4.1 is detected in the developing spinal cord, hindbrain, mesencephalon, and telencephalon [6].

Other interactions of Uncx4.1

• However, the staining for Uncx4.1 revealed that, in the N-cadherin mutants, each somite tended to be cleaved at the border between the Uncx4 [7].
• Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse [8].

References