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Adamts20  -  a disintegrin-like and metallopeptidase...

Mus musculus

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 20, ADAM-TS 20, ADAM-TS20, ADAMTS-20, Adamst20, ...
 
 
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Disease relevance of Adamts20

  • Western blot analysis using polyclonal antibodies raised against recombinant ADAMTS-20 produced in Escherichia coli showed the presence of a 70-kDa band in mouse brain and testis extracts [1].
 

High impact information on Adamts20

  • Expression analysis demonstrated that ADAMTS-20 transcripts can be detected at low levels in several human and mouse tissues, especially in testis [1].
  • ADAMTS20 is very sparingly expressed, although it is detectable in epithelial cells of the breast and lung [2].
  • The gene is located on chromosome 15, between uw and bt [3].
  • In contrast to Adamts20, we previously showed by Northern blotting that Adamts9 was expressed highly throughout mouse development [4].
  • Although expressed at generally low levels in embryonic subectodermal mesenchyme, ADAMTS20 is required for melanoblast colonization of skin [4].
 

Biological context of Adamts20

  • Three-point linkage analysis established th location of Gpt-1 on chromosome 15 between uw and bt [5].

References

  1. Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. Llamazares, M., Cal, S., Quesada, V., López-Otín, C. J. Biol. Chem. (2003) [Pubmed]
  2. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. Somerville, R.P., Longpre, J.M., Jungers, K.A., Engle, J.M., Ross, M., Evanko, S., Wight, T.N., Leduc, R., Apte, S.S. J. Biol. Chem. (2003) [Pubmed]
  3. The genetics of blind--a lethal factor in mice. Teicher, L.S., Caspari, E.W. J. Hered. (1978) [Pubmed]
  4. Adamts9 is widely expressed during mouse embryo development. Jungers, K.A., Le Goff, C., Somerville, R.P., Apte, S.S. Gene Expr. Patterns (2005) [Pubmed]
  5. Chromosomal location of soluble glutamic-pyruvic transaminase-1 (Gpt-1) in the mouse. Eicher, E.M., Womack, J.E. Biochem. Genet. (1977) [Pubmed]
 
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