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Safb  -  scaffold attachment factor B

Mus musculus

Synonyms: 3110021E02Rik, 5330423C17Rik, AU018122, D18386, E130307D12, ...
 
 
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Disease relevance of Safb

 

Psychiatry related information on Safb

  • After drug treatment, HET mice showed changes in complex behaviors, including male agonistic behavior, female postpartum aggression, and tactile discrimination performance [5].
 

High impact information on Safb

  • Immortalized SAFB1-/- mouse embryonic fibroblasts showed cell-intrinsic defects including increased transcriptional estrogen receptor alpha activity and enhanced responsiveness to IGF1 [1].
  • To assess the role of SAFB1 in vivo, we generated SAFB1 mutant mice through targeted deletion in embryonic stem cells [1].
  • Male SAFB1 null mice were infertile, apparently because of low circulating levels of testosterone [1].
  • Here, we show that genetic deletion of SAFB1 in mouse embryonic fibroblasts (MEF) leads to spontaneous immortalization and altered expression of two proteins involved in immortalization and escape from senescence: low levels of p19(ARF) and high levels of TBX2 [6].
  • Scaffold attachment factor B1 (SAFB1) is a multifunctional protein, which has previously been implicated in breast cancer [6].
 

Biological context of Safb

  • We have previously shown that SAFB1 can repress estrogen receptor (ERalpha)-mediated transactivation [7].
  • We show here that SAFB1 has a very broad tissue expression profile in human and is also expressed all along mouse embryogenesis [8].
  • SAFB1 loss also caused lack of contact inhibition, increased foci formation, and increased oncogene-induced anchorage-independent growth [6].
  • Inactivation of TBX2 using a dominant-negative TBX2 resulted in up-regulation of p19(ARF) in SAFB1 knockout MEFs [6].
  • These bone phenotypes include greater structural and apparent material properties in HBM HET as compared to non-transgenic littermates (NTG) mice [9].
 

Anatomical context of Safb

 

Associations of Safb with chemical compounds

  • The present series of experiments investigated behavioral changes in HET mice following administration of kanamycin, one of the aminoglycoside antibiotics [5].
  • We examined the effects of Bu-Zhong-Yi-Qi-Tang (Japanese name: Hochu-ekki-to, HET), a traditional Chinese medicine, on IgE production and histamine release in mice immunized intraperitoneally with a mixture of ovalbumin (OA) and aluminum hydroxide (alum adjuvant) [4].
 

Analytical, diagnostic and therapeutic context of Safb

  • Body size and weight in HBM HET were similar to that in NTG control mice [9].
  • KO and HET mice already possess femora of larger periosteal circumference than their WT littermates and ligation in these bones did not result in an increase in perimeter relative to sham [12].
  • OBJECTIVE: To investigate the effect of hochu-ekki-to (HET) decoction on the development of collagen-induced arthritis (CIA) in mice [13].

References

  1. Scaffold attachment factor B1 functions in development, growth, and reproduction. Ivanova, M., Dobrzycka, K.M., Jiang, S., Michaelis, K., Meyer, R., Kang, K., Adkins, B., Barski, O.A., Zubairy, S., Divisova, J., Lee, A.V., Oesterreich, S. Mol. Cell. Biol. (2005) [Pubmed]
  2. HET/SAF-B overexpression causes growth arrest and multinuclearity and is associated with aneuploidy in human breast cancer. Townson, S.M., Sullivan, T., Zhang, Q., Clark, G.M., Osborne, C.K., Lee, A.V., Oesterreich, S. Clin. Cancer Res. (2000) [Pubmed]
  3. Altered force-frequency response in non-failing hearts with decreased SERCA pump-level. Huke, S., Liu, L.H., Biniakiewicz, D., Abraham, W.T., Periasamy, M. Cardiovasc. Res. (2003) [Pubmed]
  4. Suppressive effects of Hochu-ekki-to, a traditional Chinese medicine, on IgE production and histamine release in mice immunized with ovalbumin. Suzuki, T., Takano, I., Nagai, F., Fujitani, T., Ushiyama, K., Okubo, T., Seto, T., Ikeda, S., Kano, I. Biol. Pharm. Bull. (1999) [Pubmed]
  5. Behavioral analysis of kanamycin administration to mice. Perdue, V.P., Eastman, W.W., Burright, R.G., Donovick, P.J. Neurotoxicology (1984) [Pubmed]
  6. Disruption of Scaffold Attachment Factor B1 Leads to TBX2 Up-regulation, Lack of p19ARF Induction, Lack of Senescence, and Cell Immortalization. Dobrzycka, K.M., Kang, K., Jiang, S., Meyer, R., Rao, P.H., Lee, A.V., Oesterreich, S. Cancer Res. (2006) [Pubmed]
  7. Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain. Townson, S.M., Kang, K., Lee, A.V., Oesterreich, S. J. Biol. Chem. (2004) [Pubmed]
  8. Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity. Debril, M.B., Dubuquoy, L., Feige, J.N., Wahli, W., Desvergne, B., Auwerx, J., Gelman, L. J. Mol. Endocrinol. (2005) [Pubmed]
  9. Bone biomechanical properties in LRP5 mutant mice. Akhter, M.P., Wells, D.J., Short, S.J., Cullen, D.M., Johnson, M.L., Haynatzki, G.R., Babij, P., Allen, K.M., Yaworsky, P.J., Bex, F., Recker, R.R. Bone (2004) [Pubmed]
  10. Immune function in lines of mice selected for high or low degrees of behavioral asymmetry. Fride, E., Collins, R.L., Skolnick, P., Arora, P.K. Brain Behav. Immun. (1990) [Pubmed]
  11. Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line. Park, H.I., Jeong, M.H., Lim, Y.J., Park, B.S., Kim, G.C., Lee, Y.M., Kim, H.M., Yoo, K.S., Yoo, Y.H. Life Sci. (2001) [Pubmed]
  12. COX-2 is necessary for venous ligation-mediated bone adaptation in mice. Stevens, H.Y., Meays, D.R., Yeh, J., Bjursten, L.M., Frangos, J.A. Bone (2006) [Pubmed]
  13. Suppressive effect of hochu-ekki-to on collagen induced arthritis in DBA1J mice. Hai, l.e. .X., Kogure, T., Niizawa, A., Fujinaga, H., Sakakibara, I., Shimada, Y., Watanabe, H., Terasawa, K. J. Rheumatol. (2002) [Pubmed]
 
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