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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Bpifb1  -  BPI fold containing family B, member 1

Mus musculus

Synonyms: BPI fold-containing family B member 1, LPlunc1, Long palate, lung and nasal epithelium carcinoma-associated protein 1, Lplunc1, U46068, ...
 
 
 
 
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High impact information on U46068

  • This expression pattern of Lplunc1 highly overlaps with that of Nodal, a major player during the L-R formation [1].
  • Interestingly, this asymmetric expression pattern is randomized in the iv mutant and reversed in the inv mutant, indicating that LPlunc1 is downstream of iv and inv [1].
  • LPlunc1 protein is secreted as a processed form of relative molecular mass 54K-60K and shares sequence features with the other members of BPI/PLUNC superfamily, including the N-terminal and C-terminal homology domains, each of which is considered to form a lipid binding pocket [1].

References

  1. Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Hou, J., Yashiro, K., Okazaki, Y., Saijoh, Y., Hayashizaki, Y., Hamada, H. Dev. Dyn. (2004) [Pubmed]
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