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Gene Review

Gba2  -  glucosidase beta 2

Mus musculus

Synonyms: Beta-glucocerebrosidase 2, Beta-glucosidase 2, Glucosylceramidase 2, Kiaa1605, NLGase, ...
 
 
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Disease relevance of Gba2

 

High impact information on Gba2

  • Our studies establish a critical role for G9a methyltransferase, histone deacetylases, and the Swi/Snf-Brm complex in the SHP-mediated inhibition of hepatic bile acid synthesis via coordinated chromatin modification at target genes [3].
  • LCA and BDL resistance in transgenic mice was associated with increased expression of bile acid-detoxifying sulfotransferase 2A (Sult2a) and selected bile acid transporters, whereas basal expression of these gene products was reduced in the LXR DKO mice [1].
  • However, neither hepatic output of VLDL cholesterol and triglycerides nor biliary lipid and fecal bile acid excretion were changed in CETP Tg compared to nTg mice [4].
  • A weak cytostatic effect of BANB-1, BANB-2 and BANB-3 was detected even in CHO cells stably transfected with rat bile acid transporters (Ntcp and Oatp1/1a1) [5].
  • In conclusion, although CETP expression facilitates cholesteryl ester tissue uptake, it does not alter biliary lipid and fecal bile acid excretion, the mandatory final step of the reverse cholesterol transport [4].
 

Biological context of Gba2

 

Other interactions of Gba2

  • In contrast to what has been observed in mice and rat studies, SHP induction did not result in repression of sodium-dependent bile acid cotransporter expression [7].

References

  1. Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Uppal, H., Saini, S.P., Moschetta, A., Mu, Y., Zhou, J., Gong, H., Zhai, Y., Ren, S., Michalopoulos, G.K., Mangelsdorf, D.J., Xie, W. Hepatology (2007) [Pubmed]
  2. Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. Kim, M.S., Sweeney, T.R., Shigenaga, J.K., Chui, L.G., Moser, A., Grunfeld, C., Feingold, K.R. Metab. Clin. Exp. (2007) [Pubmed]
  3. Coordinated Recruitment of Histone Methyltransferase G9a and Other Chromatin-Modifying Enzymes in SHP-Mediated Regulation of Hepatic Bile Acid Metabolism. Fang, S., Miao, J., Xiang, L., Ponugoti, B., Treuter, E., Kemper, J.K. Mol. Cell. Biol. (2007) [Pubmed]
  4. CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion. Harada, L.M., Amigo, L., Cazita, P.M., Salerno, A.G., Rigotti, A.A., Quintão, E.C., Oliveira, H.C. Atherosclerosis (2007) [Pubmed]
  5. Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases. Vallejo, M., Castro, M.A., Medarde, M., Macias, R.I., Romero, M.R., El-Mir, M.Y., Monte, M.J., Briz, O., Serrano, M.A., Marin, J.J. Biochem. Pharmacol. (2007) [Pubmed]
  6. Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. Yamagata, K., Yoshimochi, K., Daitoku, H., Hirota, K., Fukamizu, A. Int. J. Mol. Med. (2007) [Pubmed]
  7. Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Jung, D., Elferink, M.G., Stellaard, F., Groothuis, G.M. Liver Int. (2007) [Pubmed]
 
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