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CUL9  -  cullin 9

Homo sapiens

Synonyms: CUL-9, Cullin-9, H7AP1, KIAA0708, PARC, ...
 
 
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Disease relevance of PARC

 

High impact information on PARC

 

Biological context of PARC

  • In our cohort of beta-thalassemic patients, CCL18/PARC showed a significant negative correlation to iron chelation therapy and a significant positive correlation to ferritin and chitotriosidase levels, the latter only in the patients with the wild type genotype for the enzyme [2].
  • The acceptance of a pregnant female by the dominant male of a family group of alpine marmots (Marmota marmota) (population of La Grande Sassière, Parc national de la Vanoise, French Alps) was revealed by the combined results from microsatellite polymorphism analysis and behavioural studies [6].
 

Anatomical context of PARC

 

Associations of PARC with chemical compounds

  • The threshold dose for Ca(2+) mobilization as determined fluorometrically in indo 1-AM-labeled monocytes was 5 nM; maximal response was reached with approximately 50 nM PARC [5].
 

Physical interactions of PARC

  • Parc directly interacts and forms a approximately 1 MDa complex with p53 in the cytoplasm of unstressed cells [1].
  • Multidimensional protein identification technology analysis revealed that the CUL7 interaction with FBXW8 was mutually exclusive of CUL7 binding to PARC or p53 [7].
 

Other interactions of PARC

  • Parc: a cytoplasmic anchor for p53 [1].
  • The CCL18/PARC levels are lower than in Gaucher patients (range 174.8-10798.7, median 2538.2 ng/ml, n=28, P<0.001) [2].
  • The ratios of increments of PARC to that of PTRC, delta ARC/delta TRC, were 48.3 +/- 22.3, 35.1 +/- 10.4 and 8.4 +/- 8.1% in groups A, B, C, respectively; all of which were significantly lower than 84.2 +/- 48.6% in the control subjects [3].
 

Analytical, diagnostic and therapeutic context of PARC

  • Furthermore, PARC protein was detected by ELISA in the supernatants of eosinophils from seven of nine donors and in higher concentration in the supernatants of monocytes on day 1 of culture [5].

References

  1. Parc: a cytoplasmic anchor for p53. Nikolaev, A.Y., Li, M., Puskas, N., Qin, J., Gu, W. Cell (2003) [Pubmed]
  2. Elevated plasma chemokine CCL18/PARC in beta-thalassemia. Dimitriou, E., Verhoek, M., Altun, S., Karabatsos, F., Moraitou, M., Youssef, J., Boot, R., Sarafidou, J., Karagiorga, M., Aerts, H., Michelakakis, H. Blood Cells Mol. Dis. (2005) [Pubmed]
  3. Altered synthesis of renin in patients with insulin-dependent diabetes: plasma prorenin as a marker predicting the evolution of nephropathy. Amemiya, S., Ishihara, T., Higashida, K., Kusano, S., Ohyama, K., Kato, K. Diabetes Res. Clin. Pract. (1990) [Pubmed]
  4. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. Pivarcsi, A., Gombert, M., Dieu-Nosjean, M.C., Lauerma, A., Kubitza, R., Meller, S., Rieker, J., Muller, A., Da Cunha, L., Haahtela, A., Sonkoly, E., Fridman, W.H., Alenius, H., Kemeny, L., Ruzicka, T., Zlotnik, A., Homey, B. J. Immunol. (2004) [Pubmed]
  5. Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. Schraufstatter, I., Takamori, H., Sikora, L., Sriramarao, P., DiScipio, R.G. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  6. [Immigration of a pregnant female in an alpine marmot family group: behavioural and genetic data]. Goossens, B., Coulon, J., Allaine, D., Graziani, L., Bel, M.C., Taberlet, P. C. R. Acad. Sci. III, Sci. Vie (1996) [Pubmed]
  7. PARC and CUL7 form atypical cullin RING ligase complexes. Skaar, J.R., Florens, L., Tsutsumi, T., Arai, T., Tron, A., Swanson, S.K., Washburn, M.P., DeCaprio, J.A. Cancer Res. (2007) [Pubmed]
 
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