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Gene Review

Cytl1  -  cytokine-like 1

Mus musculus

Synonyms: 4930443F05Rik, 4Cytl1, C17, Cyt1, Gm147
 
 
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Disease relevance of Cytl1

 

High impact information on Cytl1

  • Spermatid maturation was eliminated by low doses of E2 in strains such as C57BL/6J and C17/Jls [6].
  • Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties [7].
  • Cell lines (B35, B65, B103, B104, RINm5F, Rat1, PC12, C6, C17, C27, beta TC3, NB41A3, AtT-20), derived from diverse tissue origins, were investigated in order to identify homogeneous cellular sources with distinctive GABAA receptor subunits [8].
  • The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12 [9].
  • Together, these experiments reveal that certain isotypes of sPLA(2) enhance the survival of mast cells in a cytokine-like fashion by activating antiapoptotic signaling pathways independent of IL-3 and probably via sPLA(2) receptors rather than sPLA(2) catalytic products [10].
 

Biological context of Cytl1

 

Anatomical context of Cytl1

  • This study tested the hypothesis that certain secretory phospholipase A(2) (sPLA(2)) isotypes act in a cytokine-like fashion through cell surface receptors to influence mast cell survival [10].
  • Intriguingly, primary Nf1+/- astrocyte cultures failed to demonstrate a cell-autonomous growth advantage unless they were cocultured with C17 neuronal cells [14].
  • When co-cultured with either primary astrocytes from rat cerebellum or the U251 line, the C17 cells induced a rapid cessation of glial cell division as well as complex astrocytic process extension [1].
  • However, 3T3-L1 adipocytes were unusual, in that 20% of their triglyceride fatty acids were C15 or C17 in length, observed by both MS of saponified triglycerides and electrospray MS of intact triglycerides [15].
  • Fixed C17 cells as well as partially purified C17 membranes were also potent inhibitors of astrocytic proliferation, suggesting that the gliastatic effect of the C17 cell line is membrane associated [1].
 

Associations of Cytl1 with chemical compounds

  • Indeed, the other AKR enzymes that significantly reduce keto groups situated at position C17 of the steroid nucleus, the human type 3 3alpha-HSD (h3alpha-HSD3), the human and mouse type 5 17beta-HSD, and the rabbit 20alpha-HSD, produce only 17beta-hydroxy derivatives, although they possess more than 70% amino acid identity with m17alpha-HSD [16].
  • Lung tumour incidence in mice fed with hydrazine sulphate (1.1 mg/day/mouse) was studied in male and female mice of Swiss, Strong "A" and F1 cross of ICRC (female) X C3H (Jax) (male), as well as in C17 males [2].
  • The observations on the effect of 3 agents--1,4-dinitrosopiperazine, betel nut and saccharin fed to C17 mice in combination is presented in this report [17].
  • The 3-hydroxy- and 3-methoxy-N-alkylmorphinan-6-ones of B/C-cis and -trans stereochemistry include compounds exhibiting structural variation at five positions [N-methyl (C17), oxygen at C3, C4-C5 oxygen bridge, alkyl substituents at C7 and C8] [18].
  • Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination [17].
 

Regulatory relationships of Cytl1

 

Other interactions of Cytl1

  • To develop a murine model of MV-induced pathology, we generated several lines of transgenic mice ubiquitously expressing as the MV receptor a human CD46 molecule with either a Cyt1 or Cyt2 cytoplasmic tail [20].
  • These data suggest that phase 2 inducers may exert anti-inflammatory effects by inhibiting secretion of the cytokine-like nuclear protein HMGB1 [21].
  • Our previous study (1) demonstrated the "cytokine-like" activity of poly(Glu60,Phe40)(GPhe) in augmenting the antigen-dependent proliferation of a variety of long-term murine T cell lines, particularly the bulk, BALB/c anti-poly (Glu36,Lys24,Ala40) (GLA), interleukin-4-producing, DCL-2 T cell line [22].
  • The data presented show, for the first time, that mitogen stimulated trout sIgM(-) leucocytes secrete a cytokine like growth factor sharing functional and structural similarities with mammalian IL-2 [23].

References

  1. C17, a retrovirally immortalized neuronal cell line, inhibits the proliferation of astrocytes and astrocytoma cells by a contact-mediated mechanism. Weinstein, D.E., Shelanski, M.L., Liem, R.K. Glia (1990) [Pubmed]
  2. Lung tumour incidence in mice treated with hydrazine sulphate. Bhide, S.V., D'Souza, R.A., Sawai, M.M., Ranadive, K.J. Int. J. Cancer (1976) [Pubmed]
  3. Experimental studies on betel nut and tobacco carcinogenicity. Ranadive, K.J., Gothoskar, S.V., Rao, A.R., Tezabwalla, B.U., Ambaye, R.Y. Int. J. Cancer (1976) [Pubmed]
  4. Establishment and characterization of three transplantable EBV-containing nasopharyngeal carcinomas. Busson, P., Ganem, G., Flores, P., Mugneret, F., Clausse, B., Caillou, B., Braham, K., Wakasugi, H., Lipinski, M., Tursz, T. Int. J. Cancer (1988) [Pubmed]
  5. Cytokine-like substance: origin and fate in Chagas' disease a new hypothesis about the local inflammatory reaction etiopathogenesis (experimental study in white mice). Okumura, M., Pinto, P.L., Takami, R., Nunes, E.V., Guilherme, C.S., Oliveira Júnior, O.C., Gama-Rodrigues, J.J., Iriya, K. Revista do Hospital das Clínicas. (1999) [Pubmed]
  6. Genetic variation in susceptibility to endocrine disruption by estrogen in mice. Spearow, J.L., Doemeny, P., Sera, R., Leffler, R., Barkley, M. Science (1999) [Pubmed]
  7. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Rollins, B.J., Morrison, E.D., Stiles, C.D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. Tyndale, R.F., Hales, T.G., Olsen, R.W., Tobin, A.J. J. Neurosci. (1994) [Pubmed]
  9. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. Ghilardi, N., Kljavin, N., Chen, Q., Lucas, S., Gurney, A.L., De Sauvage, F.J. J. Immunol. (2004) [Pubmed]
  10. Enhancement of mast cell survival: a novel function of some secretory phospholipase A(2) isotypes. Fonteh, A.N., Marion, C.R., Barham, B.J., Edens, M.B., Atsumi, G., Samet, J.M., High, K.P., Chilton, F.H. J. Immunol. (2001) [Pubmed]
  11. The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages. Wong, T.C., Yant, S., Harder, B.J., Korte-Sarfaty, J., Hirano, A. J. Leukoc. Biol. (1997) [Pubmed]
  12. Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro. Selvaraju, R., Bernasconi, L., Losberger, C., Graber, P., Kadi, L., Avellana-Adalid, V., Picard-Riera, N., Van Evercooren, A.B., Cirillo, R., Kosco-Vilbois, M., Feger, G., Papoian, R., Boschert, U. Mol. Cell. Neurosci. (2004) [Pubmed]
  13. Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response. Dainichi, T., Maekawa, Y., Ishii, K., Zhang, T., Nashed, B.F., Sakai, T., Takashima, M., Himeno, K. Infect. Immun. (2001) [Pubmed]
  14. Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation. Gutmann, D.H., Loehr, A., Zhang, Y., Kim, J., Henkemeyer, M., Cashen, A. Oncogene (1999) [Pubmed]
  15. Characterization of 3T3-L1 storage lipid metabolism: effect of somatotropin and insulin on specific pathways. Glenn, K.C., Shieh, J.J., Laird, D.M. Endocrinology (1992) [Pubmed]
  16. Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme. Faucher, F., Pereira de J??sus-Tran, K., Cantin, L., Luu-The, V., Labrie, F., Breton, R. J. Mol. Biol. (2006) [Pubmed]
  17. Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination. Pai, S.R., Shirke, A.J., Gothoskar, S.V. Carcinogenesis (1981) [Pubmed]
  18. A Free-Wilson/Fujita-Ban analysis and prediction of the analgesic potency of some 3-hydroxy- and 3-methoxy-N-alkylmorphinan-6-one opioids. Hernández-Gallegos, Z., Lehmann, P.A. J. Med. Chem. (1990) [Pubmed]
  19. Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter. Burkhardt, B.R., Yang, M.C., Robert, C.E., Greene, S.R., McFadden, K.K., Yang, J., Wu, J., Gao, Z., Wolf, B.A. Biochim. Biophys. Acta (2005) [Pubmed]
  20. Productive measles virus brain infection and apoptosis in CD46 transgenic mice. Evlashev, A., Moyse, E., Valentin, H., Azocar, O., Trescol-Biémont, M.C., Marie, J.C., Rabourdin-Combe, C., Horvat, B. J. Virol. (2000) [Pubmed]
  21. The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells. Killeen, M.E., Englert, J.A., Stolz, D.B., Song, M., Han, Y., Delude, R.L., Kellum, J.A., Fink, M.P. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  22. Enhanced proliferation of murine T cell lines following interaction of poly(Glu60,Phe40) (GPhe) and antigen-presenting accessory cells. II. The role of accessory cells and cytokines in the activity of GPhe on antigen-independent proliferation. Grun, J.L., Liu, D.C., Maurer, P.H. Cell. Immunol. (1990) [Pubmed]
  23. Rainbow trout (Oncorhynchus mykiss) sIgM- leucocytes secrete an interleukin-2 like growth factor after mitogenic stimulation in vitro. Blohm, U., Siegl, E., Köllner, B. Fish Shellfish Immunol. (2003) [Pubmed]
 
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