High impact information on PACS2

• Together, our results identify PACS-2 as a novel sorting protein that links the ER-mitochondria axis to ER homeostasis and the control of cell fate, and provide new insights into Bid action [1].
• However, in response to apoptotic inducers, PACS-2 translocates Bid to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated Bid, the release of cytochrome c, and the activation of caspase-3, thereby causing cell death [1].
• PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis [1].
• PACS-2 controls the apposition of mitochondria with the ER, as depletion of PACS-2 causes BAP31-dependent mitochondria fragmentation and uncoupling from the ER [1].
• PACS-2 also controls formation of ER lipid-synthesizing centers found on mitochondria-associated membranes and ER homeostasis [1].

Anatomical context of PACS2

• In the endoplasmic reticulum, newly synthesized CD31 was degraded by proteasomes, which required binding of phosphofurin acidic cluster sorting protein-2 (PACS-2) to acidic residues in the carboxyterminal tail of K5 [2].

Associations of PACS2 with chemical compounds

• A method is described for the determination of tributyltin (TBT) in NRCC sediment CRM PACS-2 by isotope dilution (ID) analysis using HPLC-ICPMS [3].
• Evaluation of accelerated solvent extraction for butyltin speciation in PACS-2 CRM using double-spike isotope dilution-GC/ICPMS [4].
• The dibutyltin (DBT; 1.14 +/- 0.02 micrograms g-1) and tributyltin (TBT; 1.01 +/- 0.04 micrograms g-1) values observed in PACS-2 sediment closely matched the certified values (DBT, 1.09 +/- 0.15; TBT, 0.98 +/- 0.13 microgram g-1 as tin) [5].

Other interactions of PACS2

• One third of attendances were treated and discharged quickly, allowing the consulting room and PACS 1/PACS 2 doctors to act more efficiently [6].
• For the three extraction techniques tested, the DBT and TBT concentration values obtained for PACS-2 closely matched the certified values [7].
• Overall uncertainties associated with the present method were estimated, where the sediment certified reference materials, PACS-2 and BCR 646, were analyzed [8].

References