The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PACS2  -  phosphofurin acidic cluster sorting protein 2

Homo sapiens

Synonyms: KIAA0602, PACS-2, PACS1-like protein, PACS1L, Phosphofurin acidic cluster sorting protein 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PACS2

  • Together, our results identify PACS-2 as a novel sorting protein that links the ER-mitochondria axis to ER homeostasis and the control of cell fate, and provide new insights into Bid action [1].
  • However, in response to apoptotic inducers, PACS-2 translocates Bid to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated Bid, the release of cytochrome c, and the activation of caspase-3, thereby causing cell death [1].
  • PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis [1].
  • PACS-2 controls the apposition of mitochondria with the ER, as depletion of PACS-2 causes BAP31-dependent mitochondria fragmentation and uncoupling from the ER [1].
  • PACS-2 also controls formation of ER lipid-synthesizing centers found on mitochondria-associated membranes and ER homeostasis [1].
 

Anatomical context of PACS2

 

Associations of PACS2 with chemical compounds

  • A method is described for the determination of tributyltin (TBT) in NRCC sediment CRM PACS-2 by isotope dilution (ID) analysis using HPLC-ICPMS [3].
  • Evaluation of accelerated solvent extraction for butyltin speciation in PACS-2 CRM using double-spike isotope dilution-GC/ICPMS [4].
  • The dibutyltin (DBT; 1.14 +/- 0.02 micrograms g-1) and tributyltin (TBT; 1.01 +/- 0.04 micrograms g-1) values observed in PACS-2 sediment closely matched the certified values (DBT, 1.09 +/- 0.15; TBT, 0.98 +/- 0.13 microgram g-1 as tin) [5].
 

Other interactions of PACS2

  • One third of attendances were treated and discharged quickly, allowing the consulting room and PACS 1/PACS 2 doctors to act more efficiently [6].
  • For the three extraction techniques tested, the DBT and TBT concentration values obtained for PACS-2 closely matched the certified values [7].
  • Overall uncertainties associated with the present method were estimated, where the sediment certified reference materials, PACS-2 and BCR 646, were analyzed [8].

References

  1. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. Simmen, T., Aslan, J.E., Blagoveshchenskaya, A.D., Thomas, L., Wan, L., Xiang, Y., Feliciangeli, S.F., Hung, C.H., Crump, C.M., Thomas, G. EMBO J. (2005) [Pubmed]
  2. Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells. Mansouri, M., Douglas, J., Rose, P.P., Gouveia, K., Thomas, G., Means, R.E., Moses, A.V., Früh, K. Blood (2006) [Pubmed]
  3. Species-specific isotope dilution-based calibration for trace element speciation and its combined uncertainty evaluation: determination of tributyltin in sediment by HPLC-ICPMS. Yang, L., Mester, Z., Sturgeon, R.E. Anal. Chem. (2002) [Pubmed]
  4. Evaluation of accelerated solvent extraction for butyltin speciation in PACS-2 CRM using double-spike isotope dilution-GC/ICPMS. Encinar, J.R., Rodriguez-González, P., Fernandez, J.R., Alonso, J.I., Díez, S., Bayona, J.M., Sanz-Medelt, A. Anal. Chem. (2002) [Pubmed]
  5. A quantitative extraction method for the determination of trace amounts of both butyl- and phenyltin compounds in sediments by gas chromatography-inductively coupled plasma mass spectrometry. Rajendran, R.B., Tao, H., Nakazato, T., Miyazaki, A. The Analyst. (2000) [Pubmed]
  6. Avoiding prolonged waiting time during busy periods in the emergency department: is there a role for the senior emergency physician in triage? Travers, J.P., Lee, F.C. European journal of emergency medicine : official journal of the European Society for Emergency Medicine (2006) [Pubmed]
  7. Evaluation of extraction techniques for the determination of butyltin compounds in sediments using isotope dilution-GC/ICPMS with 118Sn and 119Sn-enriched species. Ruiz Encinar, J., Rodriguez Gonzalez, P., García Alonso, J.I., Sanz-Medel, A. Anal. Chem. (2002) [Pubmed]
  8. Species-specific isotope dilution analysis of mono-, di, and tri-butyltin compounds in sediment using gas chromatography-inductively coupled plasma mass spectrometry with synthesized 118Sn-enriched butyltins. Inagaki, K., Takatsu, A., Watanabe, T., Aoyagi, Y., Okamoto, K. The Analyst. (2003) [Pubmed]
 
WikiGenes - Universities