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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

Dlat  -  dihydrolipoamide S-acetyltransferase (E2...

Mus musculus

Synonyms: 6332404G05Rik, DLTA, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, PDC-E2, ...
 
 
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Disease relevance of Dlat

 

High impact information on Dlat

  • Interestingly, the two AMA-negative patients that did not express PDC-E2 on the apical side of their biliary epithelium had anticentromere antibodies and Sjögren's syndrome.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • The BEC-specific cytokeratin-19 promoter and PDC-E2 gene were cloned from a mouse cDNA library [2].
  • The results indicated that aberrant PDC-E2 expression in the cytoplasm of BECs is not sufficient for the initiation of autoimmunity [2].
  • We also successfully constructed a stable KMBC cell line overexpressing the PDC-E2 [3].
  • This mature protein was highly consistent with those of previously reported rat and human PDC-E2, which possessed three structurally identifiable regions: the lipoyl-bearing domain, the E3-binding site, and the catalytic domain [3].

References

  1. Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis. Tsuneyama, K., Van De Water, J., Van Thiel, D., Coppel, R., Ruebner, B., Nakanuma, Y., Dickson, E.R., Gershwin, M.E. Hepatology (1995) [Pubmed]
  2. Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis. Inamura, K., Tsuji, H., Nakamoto, Y., Suzuki, M., Kaneko, S. Clin. Exp. Immunol. (2006) [Pubmed]
  3. Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. Wang, L., Kaneko, S., Kagaya, M., Ohno, H., Honda, M., Kobayashi, K. J. Gastroenterol. (2002) [Pubmed]
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