Disease relevance of Apeh

• Among neuroleptics studied the minimal effective doses (MED) antagonizing AP hypothermia (APH) ranged from 0.006 (trifluperidol) to 0.5 mg/kg (chlorpromazine), while MED antagonizing PRB hypothermia (PRBH) ranged from 0.05 (trifluperidol and perphenazine) to 2.0 mg/kg (haloperidol) [1].
• APH caused motor incoordination at a dosage of 125 mg/kg, and a prolonged motor impairment was present after administration of APH, 250 mg/kg [2].

Psychiatry related information on Apeh

• Amphetamine-induced stimulation of locomotor activity was not decreased by any of the other excitatory amino acid antagonists that were tested, including MK-801, 2-amino-7-phosphonoheptanoic acid (APH), or CNQX [3].

High impact information on Apeh

• The acyl-peptide hydrolase gene is 410 bp downstream of the mouse HGF-like protein, but is transcribed from the complementary strand [4].
• Tissues were extracted from VX-treated and untreated animals and tested for AChE, BChE, and acylpeptide hydrolase activity [5].
• Recent studies have demonstrated that depletion of amino acids results in the induction of several genes and that a genomic cis-element termed amino acid response element (AARE) is required for the induction [6].
• Furthermore, the convulsive threshold concentration in the brain determined by constant rate infusion of ranitidine was not affected by the pretreatment of muscimol, diazepam, APH, and MK801 [7].
• Intraperitoneal pretreatment of muscimol, aminooxy acetic acid, diazepam, (+/-)2-amino-7-phosphonoheptanoic acid (APH), or (+)MK801 suppressed the tonic convulsion after i.c. administration of ranitidine, but had no effect on clonic convulsion [7].

Biological context of Apeh

• The role of ATF2 on histone H4 acetylation is dependent on its binding to the AARE and can be extended to other amino acid regulated genes [8].

Anatomical context of Apeh

• Also, activities of acid phosphatase (APH) (10.75 +/- 0.37 IU), beta-glucuronidase (GLU) (1.55 +/- 0.07 IU) and lactate dehydrogenase (LDH) (43.3 +/- 0.7 IU) in the peritoneal macrophages in the exercise group was significantly increased (P < 0.01) [9].

Associations of Apeh with chemical compounds

• However, competitive NMDA antagonists, APH and CGS19755 did not show promotive effect on neuronal survival at up to 100 microM [10].
• Impaired motor coordination in mice induced by 2-amino-7-phosphonoheptanoic acid (APH), glutamic acid diethyl ester (GDEE), and other compounds [2].
• Impairment of motor coordination by the excitatory amino acid antagonists 2-amino-7-phosphonoheptanoic acid (APH) and glutamic acid diethyl ester (GDEE) was measured and compared to GABA agonists and anticonvulsants and other compounds by the Coughenour inverted screen test [2].

Analytical, diagnostic and therapeutic context of Apeh

• Activities of acid phosphatase (APH), beta-glucuronidase (GLU) and lactate dehydrogenase (LDH) in the peritoneal macrophages in the bon narine treated group significantly increased compared to that in the control group [11].

References