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GSPT2  -  G1 to S phase transition 2

Homo sapiens

Synonyms: ERF3B, Eukaryotic peptide chain release factor GTP-binding subunit ERF3B, Eukaryotic peptide chain release factor subunit 3b, FLJ10441, G1 to S phase transition protein 2 homolog, ...
 
 
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High impact information on GSPT2

  • In addition, we showed that eRF3b overexpression alleviated the effect of eRF3a silencing on readthrough and on eRF1 cellular levels [1].
  • In contrast, the novel gene, which was called human eRF3b (eukaryotic release factor 3b), seems to be only coamplified with c-myb [2].
  • The most distinctive elements in this signature were the gene GSTP-binding elongation factor (GSPT2) and the transcription factor HOXA9 [3].
  • Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9 [4].
 

Biological context of GSPT2

 

Anatomical context of GSPT2

 

Regulatory relationships of GSPT2

  • By measuring the readthrough at a premature nonsense codon in a reporter mRNA, we found that eRF3a silencing induced an important increase in readthrough whereas eRF3b silencing had no significant effect [1].
 

Analytical, diagnostic and therapeutic context of GSPT2

  • Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23-->p11.21 and of the distal marker DXS1039 by radiation hybrid mapping [7].

References

  1. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. Chauvin, C., Salhi, S., Le Goff, C., Viranaicken, W., Diop, D., Jean-Jean, O. Mol. Cell. Biol. (2005) [Pubmed]
  2. Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene. Wallrapp, C., Müller-Pillasch, F., Solinas-Toldo, S., Lichter, P., Friess, H., Büchler, M., Fink, T., Adler, G., Gress, T.M. Cancer Res. (1997) [Pubmed]
  3. Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III. Groene, J., Mansmann, U., Meister, R., Staub, E., Roepcke, S., Heinze, M., Klaman, I., Brümmendorf, T., Hermann, K., Loddenkemper, C., Pilarsky, C., Mann, B., Adams, H.P., Buhr, H.J., Rosenthal, A. Int. J. Cancer (2006) [Pubmed]
  4. Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9. Kasahara, M., Matsumura, E., Webb, G., Board, P.G., Figueroa, F., Klein, J. Genomics (1990) [Pubmed]
  5. Evolution of translation termination factor eRF3: is GSPT2 generated by retrotransposition of GSPT1's mRNA? Zhouravleva, G., Schepachev, V., Petrova, A., Tarasov, O., Inge-Vechtomov, S. IUBMB Life (2006) [Pubmed]
  6. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. Hoshino, S., Imai, M., Mizutani, M., Kikuchi, Y., Hanaoka, F., Ui, M., Katada, T. J. Biol. Chem. (1998) [Pubmed]
  7. Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23-->p11.21 and of the distal marker DXS1039 by radiation hybrid mapping. Hansen, L.L., Jakobsen, C.G., Justesen, J. Cytogenet. Cell Genet. (1999) [Pubmed]
 
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