The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Tbpl1  -  TATA box binding protein-like 1

Mus musculus

Synonyms: 21 kDa TBP-like protein, 4732475G08, AW011832, AW491032, D18347, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Tbpl1

 

High impact information on Tbpl1

  • Spermiogenesis deficiency in mice lacking the Trf2 gene [2].
  • We speculate that mammals may have evolved more specialized TRF2 functions in the testis that involve transcriptional regulation of genes essential for spermiogenesis [2].
  • In contrast to recent observations of an embryonic lethal phenotype for TRF2 inactivation in Caenorhabditis elegans and Xenopus laevis, we found that Trf2-deficient mice are viable [2].
  • Mice that overexpress TRF2 in the skin, K5TRF2 mice, show critically short telomeres and are susceptible to UV-induced carcinogenesis as a result of deregulated XPF/ERCC1 activity, a nuclease involved in UV damage repair [3].
  • Although the expression of the transcriptional activator CREM and many other postmeiotic genes was unaltered in TLF null mice, several spermiogenesis genes transcribed in late round spermatids appeared to be under TLF control [4].
 

Biological context of Tbpl1

 

Anatomical context of Tbpl1

  • Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene [4].
  • TRF2 expression was first detected in the late pachytene spermatocytes at stage VIII and increased throughout the subsequent stages [8].
  • Upon removal of TRF2 from TRF2(F/-) p53-/- mouse embryo fibroblasts, a telomere damage response is observed at most chromosome ends [9].
  • We now report analyses of telomerase activity, TERT mRNA levels and levels of mRNAs encoding the telomere-associated proteins TRF1 and TRF2 in three different brain regions (brainstem, hippocampus and cerebral cortex) and the eye of mice at increasing developmental time points [10].
  • In the somatic cell nuclei both proteins are present and recognized by AB against telobox peptide, but AB raised recognize only MTBP/TRF2 due to the epitope different from telobox [11].
 

Associations of Tbpl1 with chemical compounds

  • We confirm the expression of this TRP channel on SAN cells by Western blotting and RT-PCR and validate that TRPM4 is glibenclamide sensitive [12].
  • Thus, a growth factor-sensitive current, likely due to a TRP channel, is activated in vivo by exercise in native striated fibers; its deregulation in the absence of dystrophin may contribute to Ca(2+) homeostasis alteration [13].
  • Coating medical implant-quality anodized titanium surfaces (TS and TSS) with a TLF, TAST, or more specifically TIG could probably improve soft tissue adhesion and/or osseointegration of bone in vivo [14].
 

Analytical, diagnostic and therapeutic context of Tbpl1

References

  1. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Muñoz, P., Blanco, R., Flores, J.M., Blasco, M.A. Nat. Genet. (2005) [Pubmed]
  2. Spermiogenesis deficiency in mice lacking the Trf2 gene. Zhang, D., Penttila, T.L., Morris, P.L., Teichmann, M., Roeder, R.G. Science (2001) [Pubmed]
  3. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Blanco, R., Muñoz, P., Flores, J.M., Klatt, P., Blasco, M.A. Genes Dev. (2007) [Pubmed]
  4. Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene. Martianov, I., Fimia, G.M., Dierich, A., Parvinen, M., Sassone-Corsi, P., Davidson, I. Mol. Cell (2001) [Pubmed]
  5. Transcriptional repression of the mouse wee1 gene by TBP-related factor 2. Tanaka, Y., Nanba, Y.A., Park, K.A., Mabuchi, T., Suenaga, Y., Shiraishi, S., Shimada, M., Nakadai, T., Tamura, T.A. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  6. Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor. Ohbayashi, T., Makino, Y., Tamura, T.A. Nucleic Acids Res. (1999) [Pubmed]
  7. Expression of a testis-specific form of TBP-related factor 2 (TRF2) mRNA during mouse spermatogenesis. Sugiura, S., Kashiwabara, S., Iwase, S., Baba, T. J. Reprod. Dev. (2003) [Pubmed]
  8. Cell- and stage-specific high-level expression of TBP-related factor 2 (TRF2) during mouse spermatogenesis. Zhang, D., Penttila, T.L., Morris, P.L., Roeder, R.G. Mech. Dev. (2001) [Pubmed]
  9. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Celli, G.B., de Lange, T. Nat. Cell Biol. (2005) [Pubmed]
  10. Differential regulation of telomerase activity and TERT expression during brain development in mice. Klapper, W., Shin, T., Mattson, M.P. J. Neurosci. Res. (2001) [Pubmed]
  11. Nuclear envelope associated protein that binds telomeric DNAs. Podgornaya, O.I., Bugaeva, E.A., Voronin, A.P., Gilson, E., Mitchell, A.R. Mol. Reprod. Dev. (2000) [Pubmed]
  12. TRPM4, a Ca(2+)-activated nonselective cation channel in mouse sino-atrial node cells. Demion, M., Bois, P., Launay, P., Guinamard, R. Cardiovasc. Res. (2007) [Pubmed]
  13. Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: Beneficial effect of pentoxifylline. Rolland, J.F., De Luca, A., Burdi, R., Andreetta, F., Confalonieri, P., Conte Camerino, D. Neurobiol. Dis. (2006) [Pubmed]
  14. Assessment of the cytocompatibility of different coated titanium surfaces to fibroblasts and osteoblasts. Harris, L.G., Patterson, L.M., Bacon, C., Gwynn, I., Richards, R.G. Journal of biomedical materials research. Part A. (2005) [Pubmed]
  15. Telomere-binding TRF2/MTBP localization during mouse spermatogenesis and cell cycle of the mouse cells L929. Dolnik, A.V., Kuznetsova, I.S., Voronin, A.P., Podgornaya, O.I. Journal of anti-aging medicine. (2003) [Pubmed]
 
WikiGenes - Universities