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Gene Review:

Arid4a - AT rich interactive domain 4A (RBP1-like)

Mus musculus

Synonyms: A630009N03, A630067N03Rik, MmRBBP1, Rbbp1

Wu, M.Y. et al.

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High impact information on Arid4a

Importantly, mutations of Rbbp1/Arid4a, Rbbp1l1/Arid4b, or Rb suppressed an AS imprinting defect caused by a mutation at the AS-IC [1].
These data identify Rbbp1/Arid4a and Rbbp1l1/Arid4b as new members of epigenetic complexes regulating genomic imprinting at the PWS/AS domain [1].

Biological context of Arid4a

Combined homozygous deficiency for Rbbp1/Arid4a and heterozygous deficiency for Rbbp1l1/Arid4b altered epigenetic modifications at the PWS-IC with reduced trimethylation of histone H4K20 and H3K9 and reduced DNA methylation, changing the maternal allele toward a more paternal epigenotype [1].

References

Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain. Wu, M.Y., Tsai, T.F., Beaudet, A.L. Genes Dev. (2006) [Pubmed]

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