Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Fxr2 - fragile X mental retardation, autosomal...

Mus musculus

Synonyms: Fragile X mental retardation syndrome-related protein 2, Fxr2h

Spencer, C.M. et al., Mahishi, L. et al., Miyashita, A. et al., Bontekoe, C.J. et al.

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Psychiatry related information on Fxr2

Knockout mouse model for Fxr2: a model for mental retardation [1].
Our findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes [2].
Disruption of Fxr2 in mice produces learning and memory deficits, and Fmr1 and Fxr2 double-knockout mice have exaggerated impairments in certain neurobehavioral phenotypes relative to the single gene knockouts [3].

High impact information on Fxr2

Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins [2].
Plasmid rescue was used to show that the other end of the integrated vector disrupted the murine homolog of the human fragile X mental retardation syndrome-related protein 2 gene (Fxr2h) [4].

References

Knockout mouse model for Fxr2: a model for mental retardation. Bontekoe, C.J., McIlwain, K.L., Nieuwenhuizen, I.M., Yuva-Paylor, L.A., Nellis, A., Willemsen, R., Fang, Z., Kirkpatrick, L., Bakker, C.E., McAninch, R., Cheng, N.C., Merriweather, M., Hoogeveen, A.T., Nelson, D., Paylor, R., Oostra, B.A. Hum. Mol. Genet. (2002) [Pubmed]
Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins. Spencer, C.M., Serysheva, E., Yuva-Paylor, L.A., Oostra, B.A., Nelson, D.L., Paylor, R. Hum. Mol. Genet. (2006) [Pubmed]
NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2). Mahishi, L., Usdin, K. Biochem. J. (2006) [Pubmed]
Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11. Miyashita, A., Shimizu, N., Endo, N., Hanyuu, T., Ishii, N., Ito, K., Itoh, Y., Shirai, M., Nakajima, T., Odani, S., Kuwano, R. Gene (1999) [Pubmed]

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