The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hcst  -  hematopoietic cell signal transducer

Mus musculus

Synonyms: DAP10, DNAX-activation protein 10, Dap10, Hematopoietic cell signal transducer, KAP10, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Hcst

  • Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors [1].
  • In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA [1].
  • Modulation of NKG2D was mostly dependent on the YxxM motif of DAP10, the NKG2D-associated adaptor that activates phosphoinositide 3 kinase [2].
  • Natural killer (NK) cells express multiple activating receptors that initiate signaling cascades through DAP10- or immunoreceptor tyrosine-based activation motif-containing adapters, including DAP12 and FcRgamma [3].
  • Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity [3].

Anatomical context of Hcst

  • Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics [4].

Associations of Hcst with chemical compounds

  • Herein, we identify Vav1, a Rho GTPase guanine nucleotide exchange factor, as a critical signaling mediator downstream of DAP10 in NK cells [4].

Other interactions of Hcst

  • Co-immunoprecipitation experiments to identify associated adaptor proteins revealed a 10-12-kDa protein associated with SIRPbeta1 that was tyrosine-phosphorylated after PMN stimulation and is not DAP10/12 or Fc receptor gamma chain [5].


  1. An activating immunoreceptor complex formed by NKG2D and DAP10. Wu, J., Song, Y., Bakker, A.B., Bauer, S., Spies, T., Lanier, L.L., Phillips, J.H. Science (1999) [Pubmed]
  2. Impairment of NK cell function by NKG2D modulation in NOD mice. Ogasawara, K., Hamerman, J.A., Hsin, H., Chikuma, S., Bour-Jordan, H., Chen, T., Pertel, T., Carnaud, C., Bluestone, J.A., Lanier, L.L. Immunity (2003) [Pubmed]
  3. Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. Cella, M., Fujikawa, K., Tassi, I., Kim, S., Latinis, K., Nishi, S., Yokoyama, W., Colonna, M., Swat, W. J. Exp. Med. (2004) [Pubmed]
  4. Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. Graham, D.B., Cella, M., Giurisato, E., Fujikawa, K., Miletic, A.V., Kloeppel, T., Brim, K., Takai, T., Shaw, A.S., Colonna, M., Swat, W. J. Immunol. (2006) [Pubmed]
  5. SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. Liu, Y., Soto, I., Tong, Q., Chin, A., Bühring, H.J., Wu, T., Zen, K., Parkos, C.A. J. Biol. Chem. (2005) [Pubmed]
WikiGenes - Universities