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Gene Review

Osr1  -  odd-skipped related 1 (Drosophila)

Mus musculus

Synonyms: Odd1, Osr, Protein odd-skipped-related 1
 
 
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High impact information on Osr1

  • Odd1 is the earliest known marker of the intermediate mesoderm, the precursor to all kidney tissue [1].
  • Finally, persistent expression of Odd1 in chick mesonephric precursor cells inhibits differentiation of these precursors into kidney tubules [1].
  • Furthermore, homozygous Odd 1(-/-) mutant embryos exhibit complete agenesis of adrenal glands, metanephric kidneys, gonads, and defects in pericardium formation [2].
  • In contrast to other transcription factors implicated in atrial septum development, Odd 1 mRNA expression is restricted to the central dorsal domain of the atrial myocardium during normal heart development [2].
  • We have generated mice carrying a targeted null mutation in the Odd 1 gene and show that Odd 1 is essential for heart and intermediate mesoderm development [2].
 

Biological context of Osr1

 

Other interactions of Osr1

  • Special emphasis in this study was laid on the investigation of cOsr1 and cOsr2 in limb development, where we compared their expression pattern with the expression of Osr1 and Osr2 in the mouse [4].
  • In mammals two paralogs exist, Osr1 and Osr2, with functions described in heart and urogenital, and in secondary palate development, respectively [4].

References

  1. Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. James, R.G., Kamei, C.N., Wang, Q., Jiang, R., Schultheiss, T.M. Development (2006) [Pubmed]
  2. Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Wang, Q., Lan, Y., Cho, E.S., Maltby, K.M., Jiang, R. Dev. Biol. (2005) [Pubmed]
  3. Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped. So, P.L., Danielian, P.S. Mech. Dev. (1999) [Pubmed]
  4. Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. Stricker, S., Brieske, N., Haupt, J., Mundlos, S. Gene Expr. Patterns (2006) [Pubmed]
 
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