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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Taf10  -  TAF10 RNA polymerase II, TATA box binding...

Mus musculus

Synonyms: 30kDa, AU041226, TAF(II)30, TAFII-30, TAFII30, ...
 
 
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Disease relevance of Taf10

  • The two alleles of the 30 kDa TATA-binding protein associated factor (TAF(II)30) gene, have been targeted by homologous recombination in murine F9 embryonal carcinoma cells and subsequently disrupted using a Cre recombinase-loxP strategy [1].
 

High impact information on Taf10

  • Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes [1].
  • In contrast, the RA- and cAMP-induced parietal endodermal differentiation was impaired in the TAF(II)30-null cells [1].
  • Interestingly, retinoic acid (RA) treatment prevented TAF(II)30-null cell death and induced primitive endodermal differentiation [1].
  • Thus, TAF(II)30 is not indispensable for class II gene transcription in general, but seems to be required for the expression of a subset of genes [1].
  • Cells lacking TAF(II)30 are blocked in G(1)/G(0) phase of the cell cycle and undergo apoptosis [1].
 

Biological context of Taf10

 

Associations of Taf10 with chemical compounds

  • In particular, we found that the mouse TAF(II)30 subunit of the TFIID initiation complex is markedly accumulated in NIs, even though this protein does not contain a polyglutamine stretch [3].

References

  1. Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes. Metzger, D., Scheer, E., Soldatov, A., Tora, L. EMBO J. (1999) [Pubmed]
  2. TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice. Mohan, W.S., Scheer, E., Wendling, O., Metzger, D., Tora, L. Mol. Cell. Biol. (2003) [Pubmed]
  3. SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types. Yvert, G., Lindenberg, K.S., Devys, D., Helmlinger, D., Landwehrmeyer, G.B., Mandel, J.L. Hum. Mol. Genet. (2001) [Pubmed]
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