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Vtcn1  -  V-set domain containing T cell activation...

Mus musculus

Synonyms: B7 homolog 4, B7-H4, B7h4, B7s1, B7x, ...
 
 
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Disease relevance of Vtcn1

 

High impact information on Vtcn1

 

Biological context of Vtcn1

  • Similar B7-H4 structure is also found in mouse genomic DNA in chromosome 3 [2].
  • A human B7-H4 pseudogene is identified in chromosome 20p11.1 with a single exon and two stop codons in the coding region [2].
  • In this study, we report that the genomic DNA of human B7-H4 is mapped on chromosome 1 comprised of six exons and five introns spanning 66 kb, of which exon 6 is used for alternative splicing to generate two different transcripts [2].
  • To determine the cytoprotective effects of B7-H4, we developed transfectants of human beta-cell lines CM and HP62 and islet cells transfected with the B7-H4.Ig plasmid, using empty vector transfectants as controls [6].
 

Anatomical context of Vtcn1

  • Putative receptor of B7-H4 can be upregulated on activated T cells [3].
  • However, the lack of B7-H4 did not affect hypersensitive inflammatory responses in the airway or skin that are induced by either Th1 or Th2 cells [5].
  • Therefore, Treg cells convey suppressive activity to APCs by stimulating B7-H4 expression through IL-10 [7].
  • B7-H4, a recently described member of the B7 family of cosignal molecules, is thought to be involved in the regulation of cellular and humoral immune responses through receptors on activated T and B cells [6].
 

Analytical, diagnostic and therapeutic context of Vtcn1

  • We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling [3].
  • Immunohistochemistry analysis using B7-H4-specific mAb demonstrates that B7-H4 is not expressed on the majority of normal human tissues [2].
  • Human islet cells express positive B7-H4 mRNA in RT-PCR assays, but not B7-H4 protein on cell surface in flow cytometric analyses [6].

References

  1. B7S1, a novel B7 family member that negatively regulates T cell activation. Prasad, D.V., Richards, S., Mai, X.M., Dong, C. Immunity (2003) [Pubmed]
  2. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. Choi, I.H., Zhu, G., Sica, G.L., Strome, S.E., Cheville, J.C., Lau, J.S., Zhu, Y., Flies, D.B., Tamada, K., Chen, L. J. Immunol. (2003) [Pubmed]
  3. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Sica, G.L., Choi, I.H., Zhu, G., Tamada, K., Wang, S.D., Tamura, H., Chapoval, A.I., Flies, D.B., Bajorath, J., Chen, L. Immunity (2003) [Pubmed]
  4. B7x: a widely expressed B7 family member that inhibits T cell activation. Zang, X., Loke, P., Kim, J., Murphy, K., Waitz, R., Allison, J.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Suh, W.K., Wang, S., Duncan, G.S., Miyazaki, Y., Cates, E., Walker, T., Gajewska, B.U., Deenick, E., Dawicki, W., Okada, H., Wakeham, A., Itie, A., Watts, T.H., Ohashi, P.S., Jordana, M., Yoshida, H., Mak, T.W. Mol. Cell. Biol. (2006) [Pubmed]
  6. Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway. Ou, D., Wang, X., Metzger, D.L., Ao, Z., Pozzilli, P., James, R.F., Chen, L., Warnock, G.L. Cell transplantation. (2006) [Pubmed]
  7. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. Kryczek, I., Wei, S., Zou, L., Zhu, G., Mottram, P., Xu, H., Chen, L., Zou, W. J. Immunol. (2006) [Pubmed]
 
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