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Slc1a7  -  solute carrier family 1 (glutamate...

Mus musculus

Synonyms: A930031E15Rik, EAAT5, Eaat5, Excitatory amino acid transporter 5, Solute carrier family 1 member 7
 
 
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High impact information on Slc1a7

  • Electrophysiological analyses revealed that TBOA analogs block the transport-associated currents in all five EAAT subtypes and also block leak currents in EAAT5 [1].
  • The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells [2].
  • In the mouse retina, we located EAAT5 in both cone and rod photoreceptor terminals and in axon terminals of rod bipolar cells [2].
  • In conditions for which reciprocal inhibition could be monitored, the charge carried by the EAAT5 current was 1.5 times larger than the one carried by the inhibitory postsynaptic currents received from amacrine cells [2].
  • Its kinetics indicated that EAAT5 was located close to the glutamate release site [2].
 

Anatomical context of Slc1a7

  • These results indicate that EAAT5 acts as a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals [2].
 

Associations of Slc1a7 with chemical compounds

  • For 2 ms depolarizations evoking maximal responses, the EAAT5-mediated current carried between 2 and 8 times more charge as an average inhibitory GABA or glycine postsynaptic current received spontaneously from amacrine cells, with 10 mm or 0.5 mm intracellular EGTA, respectively [2].
 

Other interactions of Slc1a7

References

  1. Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Shimamoto, K., Sakai, R., Takaoka, K., Yumoto, N., Nakajima, T., Amara, S.G., Shigeri, Y. Mol. Pharmacol. (2004) [Pubmed]
  2. The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells. Wersinger, E., Schwab, Y., Sahel, J.A., Rendon, A., Pow, D.V., Picaud, S., Roux, M.J. J. Physiol. (Lond.) (2006) [Pubmed]
  3. Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice. Cooper, T.G., Wagenfeld, A., Cornwall, G.A., Hsia, N., Chu, S.T., Orgebin-Crist, M.C., Drevet, J., Vernet, P., Avram, C., Nieschlag, E., Yeung, C.H. Biol. Reprod. (2003) [Pubmed]
 
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