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Gene Review

Podn  -  podocan

Mus musculus

Synonyms: 9430070G18, Pcan, Podocan, SLRR5A
 
 
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Disease relevance of Podn

  • We isolated a novel member of the small leucine-rich repeat (SLR) protein family, podocan, that is expressed at high levels in the HIV-1 transgenic podocytes [1].
 

High impact information on Podn

  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy [1].
  • In situ hybridization of normal kidney revealed podocan mRNA expression in podocytes and likely vascular endothelial cells within the glomerulus [1].
  • The immunohistochemical staining pattern of podocan protein in normal kidney glomeruli was consistent with that of the glomerular basement membrane, and staining was markedly increased in sclerotic glomerular lesions in the transgenic HIVAN model [1].
  • Treatment of the expressed protein with various glycoenzymes suggested that podocan is a glycoprotein containing N-linked oligosaccharides but not a classical proteoglycan [2].
  • Cells transfected with podocan showed reductions in cell growth and migration, concomitant with increased p21 expression [2].
 

Associations of Podn with chemical compounds

  • Phylogenetically, podocan represents a new class in the SLR protein gene family, an expanding protein family sharing homology with the small leucine-rich repeat proteoglycans [1].

References

  1. Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. Ross, M.D., Bruggeman, L.A., Hanss, B., Sunamoto, M., Marras, D., Klotman, M.E., Klotman, P.E. J. Biol. Chem. (2003) [Pubmed]
  2. Functional characterization of podocan, a member of a new class in the small leucine-rich repeat protein family. Shimizu-Hirota, R., Sasamura, H., Kuroda, M., Kobayashi, E., Saruta, T. FEBS Lett. (2004) [Pubmed]
 
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