Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

FRA11A - fragile site, folic acid type, rare,...

Homo sapiens

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on FRA11A

However, Northern blot analysis with a fifth candidate gene, PACS1 (phosphofurin acidic cluster sorting protein), mapped to the deletion/FRA11A overlap region showed the expression of an 8-kb transcript in HeLa and five other tumor cell lines in addition to the expected 4.5-kb transcript [1].
Fluorescence in situ hybridization studies on the first patient placed the two breakpoints near the folate-sensitive fragile sites FRA11A and FRA11B [2].
Mapping FRA11A, a folate-sensitive fragile site in human chromosome band 11q13.3 [3].
To map FRA11A, we used fluorescence in situ hybridization with yeast artificial chromosome and cosmid probes on metaphase chromosomes of patients expressing the fragile site [3].
FRA11A, a rare folate-sensitive fragile site assigned to 11q13.3, lies in an area of genomic instability associated with several diseases and amplification events [3].

Other interactions of FRA11A

PC maps to 11q13 and distal to FRA11A, localising PC to 11q13.4-->q13.5 [4].

References

A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13. Zainabadi, K., Benyamini, P., Chakrabarti, R., Veena, M.S., Chandrasekharappa, S.C., Gatti, R.A., Srivatsan, E.S. Genomics (2005) [Pubmed]
Chromosome duplications and deletions and their mechanisms of origin. Tharapel, A.T., Michaelis, R.C., Velagaleti, G.V., Laundon, C.H., Martens, P.R., Buchanan, P.D., Teague, K.E., Tharapel, S.A., Wilroy, R.S. Cytogenet. Cell Genet. (1999) [Pubmed]
Mapping FRA11A, a folate-sensitive fragile site in human chromosome band 11q13.3. Perucca-Lostanlen, D., Hecht, B.K., Courseaux, A., Grosgeorge, J., Hecht, F., Gaudray, P. Cytogenet. Cell Genet. (1997) [Pubmed]
Assignment of the human pyruvate carboxylase gene (PC) to 11q13.4 by fluorescence in situ hybridisation. Walker, M.E., Baker, E., Wallace, J.C., Sutherland, G.R. Cytogenet. Cell Genet. (1995) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.