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Disease relevance of FRA11F
- Relationship between FRA11F and 11q13 gene amplification in oral cancer [1].
High impact information on FRA11F
- Cell lines with more complex 11q rearrangements expressed FRA11F in the form of an inverted duplication, characteristic of breakage-fusion-bridge cycles [1].
Biological context of FRA11F
- Our findings suggest that gene amplification involving chromosomal band 11q13 in OSCC may be initiated by breakage at FRA11F [1].
Analytical, diagnostic and therapeutic context of FRA11F
- Examination of OSCC cell lines with 11q13 amplification using fluorescence in situ hybridization showed loss of FRA11F sequences, whereas cell lines without 11q13 amplification displayed an intact FRA11F site [1].
References
- Relationship between FRA11F and 11q13 gene amplification in oral cancer. Reshmi, S.C., Huang, X., Schoppy, D.W., Black, R.C., Saunders, W.S., Smith, D.I., Gollin, S.M. Genes Chromosomes Cancer (2007) [Pubmed]
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