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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review

Hoxb8  -  homeo box B8

Rattus norvegicus

Synonyms: Homeobox protein Hox-B8, Homeobox protein R1A, Hoxb-8
 
 
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High impact information on Hoxb8

  • Receptor binding and cGMP production assays in bovine adrenal cortex indicate that replacement of the amino-terminal segment of pBNP32 with that of rANF(99-126) enhances the affinity of the peptide for the ANF-R1A receptor subtype and its stimulation of associated guanylate cyclase activity [1].
  • Moreover, an excellent correlation is observed between the affinity of the peptides for the ANF-R1A receptor and their stimulation of particulate guanylate cyclase activity in bovine adrenal cortex (r = 0.99, p < 0.01) and rat papillary (r = 0.97, p < 0.01) membrane preparations [1].
  • Perforant pathway kindling transiently induces the mRNA expression of GABA-B receptor subtypes R1A and R2 in the adult rat hippocampus [2].
  • We examined the gene expression responses of GABA-B R1A, R1B and R2 receptor subtypes in the hippocampus of perforant pathway-kindled rats at 24 h and 28 days after 15 consecutive daily stimulations [2].
  • We found R1A expression, but not R1B expression, to be significantly induced in the dentate gyrus at 24 h [2].
 

Biological context of Hoxb8

  • We studied the specificity and signal transduction pathways involved in the thyrotrophin (TSH)-releasing activity of histones H2A, H2B and peptide MB35, a H2A fragment, using perifused and incubated dispersed rat pituitary cells and measuring TSH release by a specific R1A [3].
 

Anatomical context of Hoxb8

  • Other cell lines such as PC12, RASM and GH3 express significant but varying amounts of both ANF-R1A and ANF-R1C subtypes [4].
 

Associations of Hoxb8 with chemical compounds

  • The results presented demonstrate that specific cell types express distinct natriuretic peptide receptor subtypes and also that the newly characterized ANF-R1C subtype is regulated by ATP and serine/threonine kinases in the same way as the ANF-R1A subtype [4].

References

  1. Development of natriuretic peptide analogs selective for the atrial natriuretic factor-R1A receptor subtype. Mimeault, M., Fournier, A., Féthiere, J., De Léan, A. Mol. Pharmacol. (1993) [Pubmed]
  2. Perforant pathway kindling transiently induces the mRNA expression of GABA-B receptor subtypes R1A and R2 in the adult rat hippocampus. Francis, J., Jung, B.P., Zhang, G., Ho, W., Cheng, J., McIntyre Burnham, W., Eubanks, J.H. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  3. Thyrotropin-releasing activity of histone H2A, H2B and peptide MB35. Brown, O.A., Sosa, Y.E., Goya, R.G. Peptides (1997) [Pubmed]
  4. Distribution and regulation of natriuretic factor-R1C receptor subtypes in mammalian cell lines. Féthière, J., Graihle, R., Larose, L., Babinski, K., Ong, H., De Léan, A. Mol. Cell. Biochem. (1993) [Pubmed]
 
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