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Kir3dl1  -  killer cell immunoglobulin-like receptor,...

Mus musculus

Synonyms: Killer cell immunoglobulin-like receptor 3DL1, Kirl1, Kirl2, Krl1
 
 
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High impact information on Kir3dl1

  • The rat Kir3dl1 locus was mapped to the leukocyte receptor gene complex on chromosome 1, whereas mouse Kir3dl1 was localized to the X chromosome [1].
  • We also show that the mouse genome contains a closely related, transcribed gene, which we name Kirl2 [2].
  • Nevertheless, we hypothesize that Kirl1 is functional, for the following reasons: (1) Kirl1 mRNA is expressed at high levels in immature thymocytes; (2) Kirl1 is regulated during thymocyte development; (3) KIRL1 protein is detected in thymus [2].

References

  1. Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Hoelsbrekken, S.E., Nylenna, Ø., Saether, P.C., Slettedal, I.O., Ryan, J.C., Fossum, S., Dissen, E. J. Immunol. (2003) [Pubmed]
  2. Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X. Welch, A.Y., Kasahara, M., Spain, L.M. Immunogenetics (2003) [Pubmed]
 
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